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PPIP5K1

GENERAL INFORMATION

Gene name

 PPIP5K1

Gene description

 Diphosphoinositol pentakisphosphate kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039380
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PPIP5K1 (HGNC Symbol)

Synonyms

 HISPPD2A, IPS1, KIAA0377, VIP1

Description

 Diphosphoinositol pentakisphosphate kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010]

Chromosome

 15

Cytoband

 q15.3

Chromosome location (bp)

 43533462 - 43590253

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168781 (version 83.38)

Entrez gene

 9677

UniProt

 Q6PFW1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6PFW1

Antibodypedia

 PPIP5K1 antibodies

PROTEIN BROWSER
«
PPIP5K1-002
PPIP5K1-003
PPIP5K1-004
PPIP5K1-005
PPIP5K1-006
PPIP5K1-008
PPIP5K1-009
PPIP5K1-012
PPIP5K1-016
PPIP5K1-017
PPIP5K1-022
PPIP5K1-023
PPIP5K1-201
PPIP5K1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPIP5K1-002
ENSP00000380129
ENST00000396923
Q6PFW1 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0003993 [acid phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0016311 [dephosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
Show all
 1433 aa
159.5 kDa 		No 0
PPIP5K1-003
ENSP00000353446
ENST00000360301
Q6PFW1 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0003993 [acid phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0016311 [dephosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
Show all
 1408 aa
156.6 kDa 		No 0
PPIP5K1-004
ENSP00000353253
ENST00000360135
Q6PFW1 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0003993 [acid phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0016311 [dephosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
Show all
 1406 aa
156.3 kDa 		No 0
PPIP5K1-005
ENSP00000334779
ENST00000334933
Q6PFW1 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0003993 [acid phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0016311 [dephosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
Show all
 1408 aa
156.6 kDa 		No 0
PPIP5K1-006
ENSP00000371309
ENST00000381885
B7WPL9 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0003993 [acid phosphatase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0016311 [dephosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
Show all
 1429 aa
159 kDa 		No 0
PPIP5K1-008
ENSP00000390657
ENST00000417085
C9J5E6 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 114 aa
12.7 kDa 		No 0
PPIP5K1-009
ENSP00000405200
ENST00000431962
C9J490 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005829 [cytosol]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
Show all
 72 aa
7.8 kDa 		No 0
PPIP5K1-012
ENSP00000410563
ENST00000437065
H7C398 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0003993 [acid phosphatase activity]
GO:0005829 [cytosol]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0016311 [dephosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
Show all
 259 aa
28.5 kDa 		No 0
PPIP5K1-016
ENSP00000387999
ENST00000439195
H0Y3Y5 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005829 [cytosol]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
Show all
 196 aa
21.5 kDa 		No 0
PPIP5K1-017
ENSP00000407704
ENST00000453080
C9JZX6 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005829 [cytosol]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
Show all
 133 aa
14.8 kDa 		No 0
PPIP5K1-022
ENSP00000405106
ENST00000429176
C9J5E6 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 114 aa
12.7 kDa 		No 0
PPIP5K1-023
ENSP00000371303
ENST00000381879
F8W9A8 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0003993 [acid phosphatase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0016311 [dephosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
Show all
 1409 aa
156.6 kDa 		No 0
PPIP5K1-201
ENSP00000308773
ENST00000348806
Q6PFW1 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0003993 [acid phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0016311 [dephosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
Show all
 1406 aa
156.3 kDa 		No 0
PPIP5K1-202
ENSP00000400887
ENST00000420765
Q6PFW1 [Direct mapping]
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity]
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0003993 [acid phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006020 [inositol metabolic process]
GO:0016310 [phosphorylation]
GO:0016311 [dephosphorylation]
GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
Show all
 1433 aa
159.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.