Expression of LCMT2 in cancer - Summary

CANCER ATLAS

Gene description

Leucine carboxyl methyltransferase 2

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039401

GENE INFORMATION
Gene name	LCMT2 (HGNC Symbol)
Synonyms	KIAA0547, MGC9534, PPM2, TYW4
Description	Leucine carboxyl methyltransferase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q15.3
Chromosome location (bp)	43323649 - 43330605
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168806 (version 83.38)
Entrez gene	9836
UniProt	O60294 (UniProt - Evidence at protein level)
neXtProt	NX_O60294
Antibodypedia	LCMT2 antibodies

PROTEIN BROWSER

LCMT2-001	LCMT2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LCMT2-001 ENSP00000307214 ENST00000305641	O60294 [Direct mapping] tRNA wybutosine-synthesizing protein 4 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008168 [methyltransferase activity] GO:0008175 [tRNA methyltransferase activity] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0031591 [wybutosine biosynthetic process] GO:0032259 [methylation] Show all	686 aa 75.6 kDa	No	0
LCMT2-002 ENSP00000457403 ENST00000567039	H3BU01 [Direct mapping] tRNA wybutosine-synthesizing protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		39 aa 4.1 kDa	No	0