Expression of GFM1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

G elongation factor, mitochondrial 1

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA034764	HPA034765

GENE INFORMATION
Gene name	GFM1 (HGNC Symbol)
Synonyms	EFGM, EGF1, GFM
Description	G elongation factor, mitochondrial 1 (HGNC Symbol)
Entrez gene summary	Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q25.32
Chromosome location (bp)	158644278 - 158692575
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168827 (version 83.38)
Entrez gene	85476
UniProt	Q96RP9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96RP9
Antibodypedia	GFM1 antibodies

PROTEIN BROWSER

GFM1-001	GFM1-002	GFM1-004	GFM1-007	GFM1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GFM1-001 ENSP00000419038 ENST00000486715	Q96RP9 [Direct mapping] Elongation factor G, mitochondrial E5KND5 [Target identity:100%; Query identity:100%] Mitochondrial elongation factor G Show all	THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003746 [translation elongation factor activity] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006414 [translational elongation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070125 [mitochondrial translational elongation] Show all	751 aa 83.5 kDa	No	0
GFM1-002 ENSP00000418755 ENST00000478576	C9IZ01 [Direct mapping] Elongation factor G, mitochondrial Show all	THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003746 [translation elongation factor activity] GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0006414 [translational elongation] Show all	591 aa 66 kDa	No	0
GFM1-004 ENSP00000264263 ENST00000264263	Q96RP9 [Direct mapping] Elongation factor G, mitochondrial Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003746 [translation elongation factor activity] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006414 [translational elongation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070125 [mitochondrial translational elongation] Show all	770 aa 85.9 kDa	No	0
GFM1-007 ENSP00000417532 ENST00000464732	C9JA25 [Direct mapping] Elongation factor G, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0008152 [metabolic process] Show all	60 aa 6.7 kDa	No	0
GFM1-010 ENSP00000420272 ENST00000472383	H7C5M4 [Direct mapping] Elongation factor G, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		17 aa 1.6 kDa	No	0