Cell atlas - RNF181 - The Human Protein Atlas

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RNF181

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RNF181
Gene description	Ring finger protein 181
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA046112
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046112	MCF7	Nucleoplasm
	HPA046112	MCF7	Cytosol
	HPA046112	PC-3	Nucleoplasm
	HPA046112	PC-3	Cytosol
	HPA046112	U-2 OS	Nucleoplasm
	HPA046112	U-2 OS	Cytosol

GENE INFORMATION
Gene name	RNF181 (HGNC Symbol)
Synonyms	HSPC238
Description	Ring finger protein 181 (HGNC Symbol)
Entrez gene summary	RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]
Chromosome	2
Cytoband	p11.2
Chromosome location (bp)	85595725 - 85597613
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168894 (version 83.38)
Entrez gene	51255
UniProt	Q9P0P0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P0P0
Antibodypedia	RNF181 antibodies

PROTEIN BROWSER

RNF181-001	RNF181-004	RNF181-005	RNF181-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF181-001 ENSP00000306906 ENST00000306368	Q9P0P0 [Direct mapping] E3 ubiquitin-protein ligase RNF181 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016874 [ligase activity] GO:0051865 [protein autoubiquitination] Show all	153 aa 17.9 kDa	No	0
RNF181-004 ENSP00000415246 ENST00000456023	H7C426 [Direct mapping] E3 ubiquitin-protein ligase RNF181 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 19.3 kDa	No	0
RNF181-005 ENSP00000412025 ENST00000441634	C9J1C6 [Direct mapping] E3 ubiquitin-protein ligase RNF181 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	139 aa 16 kDa	No	0
RNF181-006 ENSP00000397109 ENST00000414390	C9J391 [Direct mapping] E3 ubiquitin-protein ligase RNF181 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.