Expression of LETM1 in cancer - Summary

CANCER ATLAS

Gene description

Leucine zipper-EF-hand containing transmembrane protein 1

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Urothelial cancer

STAINING SUMMARY

HPA011029	HPA011100

GENE INFORMATION
Gene name	LETM1
Synonyms
Description	Leucine zipper-EF-hand containing transmembrane protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	1811479 - 1856247
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168924 (version 83.38)
Entrez gene	3954
UniProt	O95202 (UniProt - Evidence at protein level)
neXtProt	NX_O95202
Antibodypedia	LETM1 antibodies

PROTEIN BROWSER

LETM1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LETM1-001 ENSP00000305653 ENST00000302787	O95202 [Direct mapping] LETM1 and EF-hand domain-containing protein 1, mitochondrial Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] GO:0042407 [cristae formation] Show all	739 aa 83.4 kDa	No	1