Tissue expression of GRM5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GRM5
Gene description	Glutamate receptor, metabotropic 5
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (cerebral cortex, caudate, hippocampus, hypothalamus)
FANTOM5:	Group enriched (caudate, hippocampus, brain)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, caudate, hippocampus, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, hippocampus, brain)

GENE INFORMATION
Gene name	GRM5 (HGNC Symbol)
Synonyms	GPRC1E, mGlu5, MGLUR5, PPP1R86
Description	Glutamate receptor, metabotropic 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Chromosome	11
Cytoband
Chromosome location (bp)	88504576 - 89065945
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168959 (version 83.38)
Entrez gene	2915
UniProt	P41594 (UniProt - Evidence at protein level)
neXtProt	NX_P41594
Antibodypedia	GRM5 antibodies

PROTEIN BROWSER

GRM5-001	GRM5-002	GRM5-003	GRM5-005	GRM5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRM5-001 ENSP00000305905 ENST00000305432	P41594 [Direct mapping] Metabotropic glutamate receptor 5 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007206 [phospholipase C-activating G-protein coupled glutamate receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0050890 [cognition] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0070062 [extracellular exosome] Show all	1180 aa 128.9 kDa	Yes	7
GRM5-002 ENSP00000376972 ENST00000393294	A8MT20 [Direct mapping] Metabotropic glutamate receptor 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	298 aa 33.6 kDa	Yes	0
GRM5-003 ENSP00000403724 ENST00000449371	H7C223 [Direct mapping] Metabotropic glutamate receptor 5 Show all	Predicted intracellular proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	87 aa 10.1 kDa	No	0
GRM5-005 ENSP00000306138 ENST00000305447	P41594 [Direct mapping] Metabotropic glutamate receptor 5 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007206 [phospholipase C-activating G-protein coupled glutamate receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007612 [learning] GO:0007626 [locomotory behavior] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0043005 [neuron projection] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0050890 [cognition] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0070062 [extracellular exosome] Show all	1212 aa 132.5 kDa	Yes	7
GRM5-201 ENSP00000405690 ENST00000455756	P41594 [Direct mapping] Metabotropic glutamate receptor 5 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007206 [phospholipase C-activating G-protein coupled glutamate receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0050890 [cognition] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0070062 [extracellular exosome] Show all	1180 aa 128.9 kDa	Yes	7