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CPLX1

GENERAL INFORMATION

Gene name

 CPLX1

Gene description

 Complexin 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (brain, cerebellum, caudate)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, cerebellum, caudate)

GENE INFORMATION

Gene name

 CPLX1 (HGNC Symbol)

Synonyms

 CPX-I

Description

 Complexin 1 (HGNC Symbol)

Entrez gene summary

 Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 784957 - 826198

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168993 (version 83.38)

Entrez gene

 10815

UniProt

 O14810 (UniProt - Evidence at protein level)

neXtProt

 NX_O14810

Antibodypedia

 CPLX1 antibodies

PROTEIN BROWSER
CPLX1-001
CPLX1-003
CPLX1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CPLX1-001
ENSP00000305613
ENST00000304062
O14810 [Direct mapping]
Complexin-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005326 [neurotransmitter transporter activity]
GO:0005829 [cytosol]
GO:0006836 [neurotransmitter transport]
GO:0006887 [exocytosis]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0014047 [glutamate secretion]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017075 [syntaxin-1 binding]
GO:0017157 [regulation of exocytosis]
GO:0019905 [syntaxin binding]
GO:0030073 [insulin secretion]
GO:0030425 [dendrite]
GO:0031201 [SNARE complex]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0043234 [protein complex]
GO:0045202 [synapse]
GO:0070032 [synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex]
GO:0070554 [synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex]
Show all
 134 aa
15 kDa 		No 0
CPLX1-003
ENSP00000425960
ENST00000505203
D6RI11 [Direct mapping]
Complexin-1
Show all
Predicted intracellular proteins
Show all
GO:0006836 [neurotransmitter transport]
GO:0019905 [syntaxin binding]
Show all
 113 aa
12.5 kDa 		No 0
CPLX1-004
ENSP00000421947
ENST00000504062
D6RAG3 [Direct mapping]
Complexin-1
Show all
Predicted intracellular proteins
Show all
GO:0006836 [neurotransmitter transport]
GO:0019905 [syntaxin binding]
Show all
 110 aa
12.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.