Expression of ATP5I in cancer - Summary

CANCER ATLAS

Gene description

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035010

GENE INFORMATION
Gene name	ATP5I
Synonyms
Description	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E (HGNC Symbol)
Entrez gene summary	Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	672436 - 674338
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169020 (version 83.38)
Entrez gene	521
UniProt	P56385 (UniProt - Evidence at protein level)
neXtProt	NX_P56385
Antibodypedia	ATP5I antibodies

PROTEIN BROWSER

ATP5I-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP5I-001 ENSP00000306003 ENST00000304312	P56385 [Direct mapping] ATP synthase subunit e, mitochondrial ATP synthase subunit e, mitochondrial, N-terminally processed Show all	Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0016887 [ATPase activity] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046034 [ATP metabolic process] Show all	69 aa 7.9 kDa	No	0