Expression of AFAP1L2 in cancer - Summary

CANCER ATLAS

Gene description

Actin filament associated protein 1-like 2

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA037843

GENE INFORMATION
Gene name	AFAP1L2 (HGNC Symbol)
Synonyms	Em:AC005383.4, FLJ14564, KIAA1914, XB130
Description	Actin filament associated protein 1-like 2 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q25.3
Chromosome location (bp)	114294824 - 114404756
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169129 (version 83.38)
Entrez gene	84632
UniProt	Q8N4X5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N4X5
Antibodypedia	AFAP1L2 antibodies

PROTEIN BROWSER

AFAP1L2-001	AFAP1L2-002	AFAP1L2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AFAP1L2-001 ENSP00000358276 ENST00000369271	Q8N4X5 [Direct mapping] Actin filament-associated protein 1-like 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007346 [regulation of mitotic cell cycle] GO:0017124 [SH3 domain binding] GO:0030296 [protein tyrosine kinase activator activity] GO:0032675 [regulation of interleukin-6 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0035591 [signaling adaptor activity] GO:0042169 [SH2 domain binding] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0061098 [positive regulation of protein tyrosine kinase activity] Show all	814 aa 90.9 kDa	No	0
AFAP1L2-002 ENSP00000303042 ENST00000304129	Q8N4X5 [Direct mapping] Actin filament-associated protein 1-like 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007346 [regulation of mitotic cell cycle] GO:0017124 [SH3 domain binding] GO:0030296 [protein tyrosine kinase activator activity] GO:0032675 [regulation of interleukin-6 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0035591 [signaling adaptor activity] GO:0042169 [SH2 domain binding] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0061098 [positive regulation of protein tyrosine kinase activity] Show all	818 aa 91.3 kDa	No	0
AFAP1L2-006 ENSP00000396781 ENST00000419268	F6QUH3 [Direct mapping] Actin filament-associated protein 1-like 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0009967 [positive regulation of signal transduction] GO:0035591 [signaling adaptor activity] Show all	312 aa 35.3 kDa	No	0