Cell atlas - MN1 - The Human Protein Atlas

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MN1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MN1
Gene description	Meningioma (disrupted in balanced translocation) 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (AF22, U-2 OS, U-2197, TIME, RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA003072
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, U-2 OS, U-2197, TIME, RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003072	HeLa	Nucleoplasm
	HPA003072	U-2 OS	Nucleoplasm
	HPA003072	U-2 OS	Cytosol

GENE INFORMATION
Gene name	MN1 (HGNC Symbol)
Synonyms	MGCR, MGCR1, MGCR1-PEN
Description	Meningioma (disrupted in balanced translocation) 1 (HGNC Symbol)
Entrez gene summary	Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.1
Chromosome location (bp)	27748277 - 27801498
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169184 (version 83.38)
Entrez gene	4330
UniProt	Q10571 (UniProt - Evidence at protein level)
neXtProt	NX_Q10571
Antibodypedia	MN1 antibodies

PROTEIN BROWSER

MN1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MN1-001 ENSP00000304956 ENST00000302326	Q10571 [Direct mapping] Probable tumor suppressor protein MN1 A0A024R1C3 [Target identity:100%; Query identity:100%] Meningioma (Disrupted in balanced translocation) 1, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001957 [intramembranous ossification] GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	1320 aa 136 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.