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Moderate to strong cytoplasmic often accompanied by membranous positivity was observed in squamous cell carcinomas, renal and urothelial cancers. Remaining cancers were mainly negative.
Several cases of melanomas, testicular, gastric, pancreatic and liver cancers along with a few squamous cell carcinomas, breast and prostate cancers showed moderate to strong nucleolar immunoreactivity. Remaining tumor cells were generally negative.
GENE INFORMATION
Gene name
SH3TC2 (HGNC Symbol)
Synonyms
CMT4C, KIAA1985
Description
SH3 domain and tetratricopeptide repeats 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein with two N-terminal Src homology 3 (SH3) domains and 10 tetratricopeptide repeat (TPR) motifs, and is a member of a small gene family. The gene product has been proposed to be an adapter or docking molecule. Mutations in this gene result in autosomal recessive Charcot-Marie-Tooth disease type 4C, a childhood-onset neurodegenerative disease characterized by demyelination of motor and sensory neurons. [provided by RefSeq, Jul 2008]
Q8TF17 [Direct mapping] SH3 domain and tetratricopeptide repeat-containing protein 2
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0022011 [myelination in peripheral nervous system] GO:0031410 [cytoplasmic vesicle] GO:0032287 [peripheral nervous system myelin maintenance] GO:0033157 [regulation of intracellular protein transport] GO:0055037 [recycling endosome] GO:1901184 [regulation of ERBB signaling pathway]
