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CXCL11

GENERAL INFORMATION

Gene name

 CXCL11

Gene description

 Chemokine (C-X-C motif) ligand 11

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix)
GTEx:Mixed
FANTOM5:Tissue enhanced (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
CAB009921
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)

GENE INFORMATION

Gene name

 CXCL11 (HGNC Symbol)

Synonyms

 b-R1, H174, I-TAC, IP-9, SCYB11, SCYB9B

Description

 Chemokine (C-X-C motif) ligand 11 (HGNC Symbol)

Entrez gene summary

 Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

Chromosome

 4

Cytoband

 q21.1

Chromosome location (bp)

 76033682 - 76041415

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169248 (version 83.38)

Entrez gene

 6373

UniProt

 O14625 (UniProt - Evidence at protein level)

neXtProt

 NX_O14625

Antibodypedia

 CXCL11 antibodies

PROTEIN BROWSER
CXCL11-001
CXCL11-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXCL11-001
ENSP00000306884
ENST00000306621
O14625 [Direct mapping]
C-X-C motif chemokine 11
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0008201 [heparin binding]
GO:0010818 [T cell chemotaxis]
GO:0030816 [positive regulation of cAMP metabolic process]
GO:0032496 [response to lipopolysaccharide]
GO:0042127 [regulation of cell proliferation]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0048248 [CXCR3 chemokine receptor binding]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
 94 aa
10.4 kDa 		Yes 0
CXCL11-003
ENSP00000425819
ENST00000503860
O14625 [Direct mapping]
C-X-C motif chemokine 11
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0008201 [heparin binding]
GO:0010818 [T cell chemotaxis]
GO:0030816 [positive regulation of cAMP metabolic process]
GO:0032496 [response to lipopolysaccharide]
GO:0042127 [regulation of cell proliferation]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0048248 [CXCR3 chemokine receptor binding]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
 94 aa
10.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.