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KCNAB1

CANCER ATLAS

Gene description

 Potassium channel, voltage gated subfamily A regulatory beta subunit 1

Protein class

 Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA044550

GENE INFORMATION

Gene name

 KCNAB1 (HGNC Symbol)

Synonyms

 AKR6A3, hKvb3, hKvBeta3, KCNA1B, Kvb1.3

Description

 Potassium channel, voltage gated subfamily A regulatory beta subunit 1 (HGNC Symbol)

Entrez gene summary

 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Apr 2015]

Chromosome

 3

Cytoband

 q25.31

Chromosome location (bp)

 156037701 - 156539138

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169282 (version 83.38)

Entrez gene

 7881

UniProt

 Q14722 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14722

Antibodypedia

 KCNAB1 antibodies

PROTEIN BROWSER
KCNAB1-001
KCNAB1-002
KCNAB1-003
KCNAB1-004
KCNAB1-006
KCNAB1-009
KCNAB1-010
KCNAB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNAB1-001
ENSP00000305858
ENST00000302490
Q14722 [Direct mapping]
Voltage-gated potassium channel subunit beta-1
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0015459 [potassium channel regulator activity]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034705 [potassium channel complex]
GO:0055114 [oxidation-reduction process]
GO:0070402 [NADPH binding]
GO:0071805 [potassium ion transmembrane transport]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
Show all
 401 aa
44.7 kDa 		No 0
KCNAB1-002
ENSP00000419952
ENST00000490337
Q14722 [Direct mapping]
Voltage-gated potassium channel subunit beta-1
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0007519 [skeletal muscle tissue development]
GO:0007611 [learning or memory]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032839 [dendrite cytoplasm]
GO:0034705 [potassium channel complex]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0044224 [juxtaparanode region of axon]
GO:0044325 [ion channel binding]
GO:0045445 [myoblast differentiation]
GO:0055114 [oxidation-reduction process]
GO:0060539 [diaphragm development]
GO:0070402 [NADPH binding]
GO:0071805 [potassium ion transmembrane transport]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:1990635 [proximal dendrite]
Show all
 419 aa
46.6 kDa 		No 0
KCNAB1-003
ENSP00000374287
ENST00000389636
B7Z8E5 [Direct mapping]
Voltage-gated potassium channel subunit beta-1; cDNA FLJ59247, highly similar to Voltage-gated potassium channel subunit beta-1
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Predicted intracellular proteins
Show all
GO:0006813 [potassium ion transport]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
Show all
 390 aa
43.3 kDa 		No 0
KCNAB1-004
ENSP00000418956
ENST00000471742
Q14722 [Direct mapping]
Voltage-gated potassium channel subunit beta-1
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0015459 [potassium channel regulator activity]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034705 [potassium channel complex]
GO:0055114 [oxidation-reduction process]
GO:0070402 [NADPH binding]
GO:0071805 [potassium ion transmembrane transport]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
Show all
 408 aa
45.5 kDa 		No 0
KCNAB1-006
ENSP00000374285
ENST00000389634
F8W6W4 [Direct mapping]
Voltage-gated potassium channel subunit beta-1
Show all
Predicted intracellular proteins
Show all
GO:0006813 [potassium ion transport]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
Show all
 372 aa
41.4 kDa 		No 0
KCNAB1-009
ENSP00000420755
ENST00000472028
C9JBV8 [Direct mapping]
Voltage-gated potassium channel subunit beta-1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
 129 aa
14.3 kDa 		No 0
KCNAB1-010
ENSP00000420221
ENST00000475456
C9JQ60 [Direct mapping]
Voltage-gated potassium channel subunit beta-1
Show all
Predicted intracellular proteins
Show all
 177 aa
19.8 kDa 		No 0
KCNAB1-201
ENSP00000484368
ENST00000618897
A0A087X1P8 [Direct mapping]
Voltage-gated potassium channel subunit beta-1
Show all
Predicted intracellular proteins
Show all
GO:0006813 [potassium ion transport]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
Show all
 304 aa
34 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.