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NR0B1

GENERAL INFORMATION

Gene name

 NR0B1

Gene description

 Nuclear receptor subfamily 0, group B, member 1

Protein class

 Cancer-related genes
Disease related genes
Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (testis, adrenal gland)
GTEx:Group enriched (adrenal gland, testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 NR0B1 (HGNC Symbol)

Synonyms

 AHC, AHCH, DAX1, DSS, NR0B1

Description

 Nuclear receptor subfamily 0, group B, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p21.2

Chromosome location (bp)

 30304206 - 30309598

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169297 (version 83.38)

Entrez gene

 190

UniProt

 P51843 (UniProt - Evidence at protein level)

neXtProt

 NX_P51843

Antibodypedia

 NR0B1 antibodies

PROTEIN BROWSER
NR0B1-001
NR0B1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR0B1-001
ENSP00000368253
ENST00000378970
P51843 [Direct mapping]
Nuclear receptor subfamily 0 group B member 1
F1D8P4 [Target identity:100%; Query identity:100%]
Nuclear receptor DAX1; Nuclear receptor subfamily 0, group B, member 1
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Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003714 [transcription corepressor activity]
GO:0003723 [RNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006694 [steroid biosynthetic process]
GO:0007283 [spermatogenesis]
GO:0007530 [sex determination]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008406 [gonad development]
GO:0008584 [male gonad development]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0019904 [protein domain specific binding]
GO:0021854 [hypothalamus development]
GO:0021983 [pituitary gland development]
GO:0030154 [cell differentiation]
GO:0030238 [male sex determination]
GO:0030325 [adrenal gland development]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032448 [DNA hairpin binding]
GO:0033144 [negative regulation of intracellular steroid hormone receptor signaling pathway]
GO:0033327 [Leydig cell differentiation]
GO:0035258 [steroid hormone receptor binding]
GO:0035902 [response to immobilization stress]
GO:0042788 [polysomal ribosome]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045596 [negative regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0050682 [AF-2 domain binding]
GO:0060008 [Sertoli cell differentiation]
Show all
 470 aa
51.7 kDa 		No 0
NR0B1-002
ENSP00000368246
ENST00000378963
A6NNU8 [Direct mapping]
Nuclear receptor subfamily 0 group B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 105 aa
11.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.