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P2RY12

GENERAL INFORMATION

Gene name

 P2RY12

Gene description

 Purinergic receptor P2Y, G-protein coupled, 12

Protein class

 Disease related genes
FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (hypothalamus, hippocampus, caudate)
FANTOM5:Tissue enhanced (caudate, brain, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic and nuclear expression in microglia and subsets of cells in bone marrow and lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA013796 , HPA014518
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hypothalamus, hippocampus, caudate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, brain, hippocampus)

GENE INFORMATION

Gene name

 P2RY12 (HGNC Symbol)

Synonyms

 HORK3, P2Y12, SP1999

Description

 Purinergic receptor P2Y, G-protein coupled, 12 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

 3

Cytoband

 q25.1

Chromosome location (bp)

 151337380 - 151384812

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169313 (version 83.38)

Entrez gene

 64805

UniProt

 Q9H244 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H244

Antibodypedia

 P2RY12 antibodies

PROTEIN BROWSER
P2RY12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
P2RY12-001
ENSP00000307259
ENST00000302632
Q9H244 [Direct mapping]
P2Y purinoceptor 12
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001609 [G-protein coupled adenosine receptor activity]
GO:0001621 [ADP receptor activity]
GO:0001973 [adenosine receptor signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0007599 [hemostasis]
GO:0008347 [glial cell migration]
GO:0009897 [external side of plasma membrane]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010700 [negative regulation of norepinephrine secretion]
GO:0016021 [integral component of membrane]
GO:0030030 [cell projection organization]
GO:0030168 [platelet activation]
GO:0031224 [intrinsic component of membrane]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0043270 [positive regulation of ion transport]
GO:0043491 [protein kinase B signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0045596 [negative regulation of cell differentiation]
GO:0051924 [regulation of calcium ion transport]
GO:0070527 [platelet aggregation]
GO:0070588 [calcium ion transmembrane transport]
GO:0071318 [cellular response to ATP]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071805 [potassium ion transmembrane transport]
GO:1904139 [regulation of microglial cell migration]
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 342 aa
39.4 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.