Expression of UMOD in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Uromodulin

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Renal cancer

STAINING SUMMARY

HPA043420	HPA054721	CAB009446

GENE INFORMATION
Gene name	UMOD
Synonyms
Description	Uromodulin (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	20333052 - 20356301
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169344 (version 83.38)
Entrez gene	7369
UniProt	P07911 (UniProt - Evidence at protein level)
neXtProt	NX_P07911
Antibodypedia	UMOD antibodies

PROTEIN BROWSER

UMOD-001	UMOD-002	UMOD-008	UMOD-009	UMOD-011	UMOD-012	UMOD-014	UMOD-015	UMOD-016	UMOD-017	UMOD-018	UMOD-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UMOD-001 ENSP00000379442 ENST00000396138	X6RBG4 [Direct mapping] Uromodulin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	689 aa 75.7 kDa	No	2
UMOD-002 ENSP00000379438 ENST00000396134	P07911 [Direct mapping] Uromodulin Uromodulin, secreted form Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0006968 [cellular defense response] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007159 [leukocyte cell-cell adhesion] GO:0007588 [excretion] GO:0008285 [negative regulation of cell proliferation] GO:0010033 [response to organic substance] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0019864 [IgG binding] GO:0019898 [extrinsic component of membrane] GO:0031225 [anchored component of membrane] GO:0031410 [cytoplasmic vesicle] GO:0045121 [membrane raft] GO:0045177 [apical part of cell] GO:0048878 [chemical homeostasis] GO:0060170 [ciliary membrane] GO:0070062 [extracellular exosome] GO:0072218 [metanephric ascending thin limb development] GO:0072221 [metanephric distal convoluted tubule development] GO:0072233 [metanephric thick ascending limb development] GO:0072372 [primary cilium] GO:1990266 [neutrophil migration] GO:2000021 [regulation of ion homeostasis] Show all	673 aa 73.6 kDa	Yes	1
UMOD-008 ENSP00000460548 ENST00000570689	P07911 [Direct mapping] Uromodulin Uromodulin, secreted form Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0006968 [cellular defense response] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007159 [leukocyte cell-cell adhesion] GO:0008285 [negative regulation of cell proliferation] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0019864 [IgG binding] GO:0019898 [extrinsic component of membrane] GO:0031225 [anchored component of membrane] GO:0060170 [ciliary membrane] GO:0070062 [extracellular exosome] GO:0072372 [primary cilium] GO:1990266 [neutrophil migration] Show all	640 aa 69.8 kDa	Yes	1
UMOD-009 ENSP00000459738 ENST00000577168	I3L2K2 [Direct mapping] Uromodulin Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	138 aa 14.9 kDa	Yes	0
UMOD-011 ENSP00000458939 ENST00000571174	I3L1M3 [Direct mapping] Uromodulin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	125 aa 13 kDa	Yes	0
UMOD-012 ENSP00000461641 ENST00000576688	I3L4Y6 [Direct mapping] Uromodulin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] Show all	103 aa 10.8 kDa	Yes	0
UMOD-014 ENSP00000459724 ENST00000570757	I3L2J2 [Direct mapping] Uromodulin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	88 aa 9.2 kDa	Yes	0
UMOD-015 ENSP00000458695 ENST00000570972	Q8NHW8 [Direct mapping] Uromodulin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	29 aa 3.1 kDa	No	0
UMOD-016 ENSP00000461120 ENST00000576546	I3L4B0 [Direct mapping] Uromodulin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	86 aa 9.1 kDa	Yes	0
UMOD-017 ENSP00000460845 ENST00000574195	I3L3Z4 [Direct mapping] Uromodulin Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] Show all	161 aa 17.6 kDa	Yes	0
UMOD-018 ENSP00000460374 ENST00000573567	I3L3E0 [Direct mapping] Uromodulin Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	161 aa 17.1 kDa	Yes	0
UMOD-201 ENSP00000306279 ENST00000302509	P07911 [Direct mapping] Uromodulin Uromodulin, secreted form Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0006968 [cellular defense response] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007159 [leukocyte cell-cell adhesion] GO:0008285 [negative regulation of cell proliferation] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0019864 [IgG binding] GO:0019898 [extrinsic component of membrane] GO:0031225 [anchored component of membrane] GO:0060170 [ciliary membrane] GO:0070062 [extracellular exosome] GO:0072372 [primary cilium] GO:1990266 [neutrophil migration] Show all	640 aa 69.8 kDa	Yes	1