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Weak to moderate nuclear membrane or nuclear positivity was observed in most malignancies. Many cells displayed additional cytoplasmic positivity. Renal carcinomas generally showed distinct staining in plasma membranes.
GENE INFORMATION
Gene name
SNUPN (HGNC Symbol)
Synonyms
RNUT1, SNURPORTIN-1, Snurportin1
Description
Snurportin 1 (HGNC Symbol)
Entrez gene summary
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]