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Gene name

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Chromosome

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Reliability

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Method

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Searches

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Cell type

Expression

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Cell line

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Detectable

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Detectable

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Antibodies

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SIN3A
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SIN3A

Gene description

SIN3 transcription regulator family member A

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear expression with highest expression in testis.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA047213 , HPA062123 , CAB004506
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

SIN3A (HGNC Symbol)

Synonyms

DKFZP434K2235, KIAA0700

Description

SIN3 transcription regulator family member A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q24.2

Chromosome location (bp)

75369379 - 75455842

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169375 (version 83.38)

Entrez gene

25942

UniProt

Q96ST3 (UniProt - Evidence at protein level)

neXtProt

NX_Q96ST3

Antibodypedia

SIN3A antibodies

PROTEIN BROWSER

«
SIN3A-001
SIN3A-002
SIN3A-003
SIN3A-004
SIN3A-005
SIN3A-006
SIN3A-007
SIN3A-008
SIN3A-013
SIN3A-014
SIN3A-015
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIN3A-001
ENSP00000378402
ENST00000394947
Q96ST3 [Direct mapping]
Paired amphipathic helix protein Sin3a
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000776 [kinetochore]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0001701 [in utero embryonic development]
GO:0002218 [activation of innate immune response]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0003723 [RNA binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0007568 [aging]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0010243 [response to organonitrogen compound]
GO:0010467 [gene expression]
GO:0010817 [regulation of hormone levels]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0016575 [histone deacetylation]
GO:0016580 [Sin3 complex]
GO:0017053 [transcriptional repressor complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0032403 [protein complex binding]
GO:0033558 [protein deacetylase activity]
GO:0034613 [cellular protein localization]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042754 [negative regulation of circadian rhythm]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045171 [intercellular bridge]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048511 [rhythmic process]
GO:0051595 [response to methylglyoxal]
GO:0071333 [cellular response to glucose stimulus]
GO:1900181 [negative regulation of protein localization to nucleus]
GO:1901675 [negative regulation of histone H3-K27 acetylation]
GO:1903351 [cellular response to dopamine]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
Show all
1273 aa
145.2 kDa
No 0
SIN3A-002
ENSP00000353622
ENST00000360439
Q96ST3 [Direct mapping]
Paired amphipathic helix protein Sin3a
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0002218 [activation of innate immune response]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0007596 [blood coagulation]
GO:0010467 [gene expression]
GO:0016575 [histone deacetylation]
GO:0016580 [Sin3 complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0033558 [protein deacetylase activity]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042754 [negative regulation of circadian rhythm]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045171 [intercellular bridge]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048511 [rhythmic process]
GO:1900181 [negative regulation of protein localization to nucleus]
GO:1901675 [negative regulation of histone H3-K27 acetylation]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
Show all
1273 aa
145.2 kDa
No 0
SIN3A-003
ENSP00000455834
ENST00000567289
H3BQL7 [Direct mapping]
Paired amphipathic helix protein Sin3a
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005654 [nucleoplasm]
GO:0016575 [histone deacetylation]
Show all
156 aa
17.1 kDa
No 0
SIN3A-004
ENSP00000378403
ENST00000394949
Q96ST3 [Direct mapping]
Paired amphipathic helix protein Sin3a
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0002218 [activation of innate immune response]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0007596 [blood coagulation]
GO:0010467 [gene expression]
GO:0016575 [histone deacetylation]
GO:0016580 [Sin3 complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0033558 [protein deacetylase activity]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042754 [negative regulation of circadian rhythm]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045171 [intercellular bridge]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048511 [rhythmic process]
GO:1900181 [negative regulation of protein localization to nucleus]
GO:1901675 [negative regulation of histone H3-K27 acetylation]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
Show all
1273 aa
145.2 kDa
No 0
SIN3A-005
ENSP00000455204
ENST00000564778
H3BP90 [Direct mapping]
Paired amphipathic helix protein Sin3a
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016575 [histone deacetylation]
Show all
176 aa
19.3 kDa
No 0
SIN3A-006
ENSP00000455662
ENST00000570115
H3BQ88 [Direct mapping]
Paired amphipathic helix protein Sin3a
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005654 [nucleoplasm]
GO:0016575 [histone deacetylation]
Show all
123 aa
13.2 kDa
No 0
SIN3A-007
ENSP00000455072
ENST00000562776
H3BNZ3 [Direct mapping]
Paired amphipathic helix protein Sin3a
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005654 [nucleoplasm]
GO:0016575 [histone deacetylation]
Show all
142 aa
15.4 kDa
No 0
SIN3A-008
ENSP00000454296
ENST00000565264
H3BMA2 [Direct mapping]
Paired amphipathic helix protein Sin3a
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
18 aa
2.2 kDa
No 0
SIN3A-013
ENSP00000456997
ENST00000568190
H3BT34 [Direct mapping]
Paired amphipathic helix protein Sin3a
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005654 [nucleoplasm]
GO:0016575 [histone deacetylation]
Show all
98 aa
10.5 kDa
No 0
SIN3A-014
ENSP00000454750
ENST00000568431
H3BNA0 [Direct mapping]
Paired amphipathic helix protein Sin3a
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005654 [nucleoplasm]
GO:0016575 [histone deacetylation]
Show all
130 aa
14 kDa
No 0
SIN3A-015
ENSP00000455644
ENST00000568309
H3BQ76 [Direct mapping]
Paired amphipathic helix protein Sin3a
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005654 [nucleoplasm]
GO:0016575 [histone deacetylation]
Show all
107 aa
11.4 kDa
No 0

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