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PTAFR

GENERAL INFORMATION

Gene name

 PTAFR

Gene description

 Platelet-activating factor receptor

Protein class

 G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix)
GTEx:Tissue enhanced (spleen)
FANTOM5:Tissue enhanced (tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in subsets of immune cells and most glandular epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA027543
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (tonsil)

GENE INFORMATION

Gene name

 PTAFR

Synonyms

Description

 Platelet-activating factor receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Chromosome

 1

Cytoband

 p35.3

Chromosome location (bp)

 28147166 - 28193936

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169403 (version 83.38)

Entrez gene

 5724

UniProt

 P25105 (UniProt - Evidence at protein level)

neXtProt

 NX_P25105

Antibodypedia

 PTAFR antibodies

PROTEIN BROWSER
PTAFR-001
PTAFR-002
PTAFR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTAFR-001
ENSP00000362965
ENST00000373857
P25105 [Direct mapping]
Platelet-activating factor receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0001816 [cytokine production]
GO:0001875 [lipopolysaccharide receptor activity]
GO:0002693 [positive regulation of cellular extravasation]
GO:0004930 [G-protein coupled receptor activity]
GO:0004992 [platelet activating factor receptor activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007567 [parturition]
GO:0009609 [response to symbiotic bacterium]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032959 [inositol trisphosphate biosynthetic process]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043315 [positive regulation of neutrophil degranulation]
GO:0045028 [G-protein coupled purinergic nucleotide receptor activity]
GO:0045056 [transcytosis]
GO:0045410 [positive regulation of interleukin-6 biosynthetic process]
GO:0045727 [positive regulation of translation]
GO:0045776 [negative regulation of blood pressure]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045909 [positive regulation of vasodilation]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046683 [response to organophosphorus]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0071258 [cellular response to gravity]
GO:0071320 [cellular response to cAMP]
GO:0071398 [cellular response to fatty acid]
GO:0071548 [response to dexamethasone]
GO:1902943 [positive regulation of voltage-gated chloride channel activity]
GO:1903039 [positive regulation of leukocyte cell-cell adhesion]
GO:1903238 [positive regulation of leukocyte tethering or rolling]
GO:1904058 [positive regulation of sensory perception of pain]
GO:1904300 [positive regulation of transcytosis]
GO:1904303 [positive regulation of maternal process involved in parturition]
GO:1904306 [positive regulation of gastro-intestinal system smooth muscle contraction]
GO:1904316 [response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine]
GO:1904317 [cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine]
Show all
 342 aa
39.2 kDa 		No 7
PTAFR-002
ENSP00000301974
ENST00000305392
P25105 [Direct mapping]
Platelet-activating factor receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004992 [platelet activating factor receptor activity]
GO:0005543 [phospholipid binding]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045028 [G-protein coupled purinergic nucleotide receptor activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060333 [interferon-gamma-mediated signaling pathway]
Show all
 342 aa
39.2 kDa 		No 7
PTAFR-201
ENSP00000442658
ENST00000539896
P25105 [Direct mapping]
Platelet-activating factor receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004992 [platelet activating factor receptor activity]
GO:0005543 [phospholipid binding]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045028 [G-protein coupled purinergic nucleotide receptor activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060333 [interferon-gamma-mediated signaling pathway]
Show all
 342 aa
39.2 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.