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RNASE6

GENERAL INFORMATION

Gene name

 RNASE6

Gene description

 Ribonuclease, RNase A family, k6

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a small subset of immune cells in tonsil, bone marrow and intestinal tract.

DATA RELIABILITY

Data reliability
description

 Pending external verification. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA000698
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RNASE6 (HGNC Symbol)

Synonyms

 RAD1, RNS6

Description

 Ribonuclease, RNase A family, k6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 20781051 - 20782467

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169413 (version 83.38)

Entrez gene

 6039

UniProt

 Q93091 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q93091

Antibodypedia

 RNASE6 antibodies

PROTEIN BROWSER
RNASE6-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNASE6-002
ENSP00000302046
ENST00000304677
Q93091 [Direct mapping]
Ribonuclease K6
Q6IB39 [Target identity:100%; Query identity:100%]
RNASE6 protein; Ribonuclease A D1; Ribonuclease, RNase A family, k6, isoform CRA_a; cDNA, FLJ94144, Homo sapiens ribonuclease, RNase A family, k6 (RNASE6), mRNA
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0004519 [endonuclease activity]
GO:0004540 [ribonuclease activity]
GO:0005576 [extracellular region]
GO:0006401 [RNA catabolic process]
GO:0006952 [defense response]
GO:0070062 [extracellular exosome]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090501 [RNA phosphodiester bond hydrolysis]
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 150 aa
17.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.