Tissue expression of KCNK9 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KCNK9
Gene description	Potassium channel, two pore domain subfamily K, member 9
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (adrenal gland, cerebral cortex)
GTEx:	Tissue enriched (cerebellum)
FANTOM5:	Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adrenal gland, cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION
Gene name	KCNK9 (HGNC Symbol)
Synonyms	K2p9.1, TASK-3, TASK3
Description	Potassium channel, two pore domain subfamily K, member 9 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	139600838 - 139703056
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169427 (version 83.38)
Entrez gene	51305
UniProt	Q9NPC2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPC2
Antibodypedia	KCNK9 antibodies

PROTEIN BROWSER

KCNK9-002	KCNK9-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNK9-002 ENSP00000430676 ENST00000520439	Q9NPC2 [Direct mapping] Potassium channel subfamily K member 9 A0A024R9H3 [Target identity:100%; Query identity:100%] Potassium channel, subfamily K, member 9, isoform CRA_b Show all	Transporters Transporter channels and pores Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008021 [synaptic vesicle] GO:0016020 [membrane] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] GO:0071804 [cellular potassium ion transport] GO:0071805 [potassium ion transmembrane transport] Show all	374 aa 42.3 kDa	No	5
KCNK9-201 ENSP00000302166 ENST00000303015	Q9NPC2 [Direct mapping] Potassium channel subfamily K member 9 A0A024R9H3 [Target identity:100%; Query identity:100%] Potassium channel, subfamily K, member 9, isoform CRA_b Show all	Transporters Transporter channels and pores Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	374 aa 42.3 kDa	No	5