Cell atlas - COL22A1 - The Human Protein Atlas

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COL22A1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Vesicles

Human cell
	Endoplasmic Reticulum
	Vesicles

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GENERAL INFORMATION
Gene name	COL22A1
Gene description	Collagen, type XXII, alpha 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the endoplasmic reticulum.
RNA cell category	Group enriched (HDLM-2, RT4, SCLC-21H, U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Additional location	In addition localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA024830
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HDLM-2, RT4, SCLC-21H, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the endoplasmic reticulum.

Main location

Vesicles (supported)

Additional location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024830	RT4	Endoplasmic reticulum
	HPA024830	RT4	Vesicles
	HPA024830	U-2 OS	Vesicles
	HPA024830	U-251 MG	Vesicles

GENE INFORMATION
Gene name	COL22A1
Synonyms
Description	Collagen, type XXII, alpha 1 (HGNC Symbol)
Entrez gene summary	COL22A1, a member of the FACIT (fibrillar-associated collagens with interrupted triple helices) subgroup of the collagen protein family, specifically localizes to tissue junctions (Koch et al., 2004 [PubMed 15016833]).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband
Chromosome location (bp)	138588235 - 138914006
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169436 (version 83.38)
Entrez gene	169044
UniProt	Q8NFW1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NFW1
Antibodypedia	COL22A1 antibodies

PROTEIN BROWSER

COL22A1-001	COL22A1-007	COL22A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL22A1-001 ENSP00000303153 ENST00000303045	Q8NFW1 [Direct mapping] Collagen alpha-1(XXII) chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005788 [endoplasmic reticulum lumen] GO:0030198 [extracellular matrix organization] Show all	1626 aa 161.1 kDa	Yes	0
COL22A1-007 ENSP00000428244 ENST00000522546	H0YAX7 [Direct mapping] Collagen alpha-1(XXII) chain Show all	Predicted intracellular proteins Show all		65 aa 6.2 kDa	No	0
COL22A1-201 ENSP00000387655 ENST00000435777	Q8NFW1 [Direct mapping] Collagen alpha-1(XXII) chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005788 [endoplasmic reticulum lumen] GO:0030198 [extracellular matrix organization] Show all	1319 aa 129.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.