Cell atlas - TM2D2 - The Human Protein Atlas

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TM2D2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Plasma membrane
	Vesicles

Human cell
	Nucleoplasm
	Plasma Membrane
	Vesicles

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GENERAL INFORMATION
Gene name	TM2D2
Gene description	TM2 domain containing 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane, nucleoplasm & vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Vesicles (approved), Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047152
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane, nucleoplasm & vesicles.

Main location

Nucleoplasm (approved), Vesicles (approved), Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047152	MCF7	Nucleoplasm
	HPA047152	MCF7	Vesicles
	HPA047152	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	TM2D2 (HGNC Symbol)
Synonyms	BLP1
Description	TM2 domain containing 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively spliced transcript variants which encode two different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p11.22
Chromosome location (bp)	38988808 - 38996824
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169490 (version 83.38)
Entrez gene	83877
UniProt	Q9BX73 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BX73
Antibodypedia	TM2D2 antibodies

PROTEIN BROWSER

TM2D2-001	TM2D2-002	TM2D2-003	TM2D2-006	TM2D2-007	TM2D2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TM2D2-001 ENSP00000416050 ENST00000456397	Q9BX73 [Direct mapping] TM2 domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	214 aa 22.9 kDa	Yes	2
TM2D2-002 ENSP00000380260 ENST00000397070	Q9BX73 [Direct mapping] TM2 domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	171 aa 19 kDa	Yes	2
TM2D2-003 ENSP00000391674 ENST00000456845	Q9BX73 [Direct mapping] TM2 domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	171 aa 19 kDa	Yes	2
TM2D2-006 ENSP00000428394 ENST00000522142	E5RIQ5 [Direct mapping] TM2 domain-containing protein 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 13.7 kDa	Yes	0
TM2D2-007 ENSP00000428203 ENST00000520152	E5RJK9 [Direct mapping] TM2 domain-containing protein 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		45 aa 5.3 kDa	No	0
TM2D2-008 ENSP00000430685 ENST00000517872	E5RIT0 [Direct mapping] TM2 domain-containing protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 7.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.