Expression of GPR183 in cancer - Summary

CANCER ATLAS

Gene description

G protein-coupled receptor 183

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028847	CAB033690

GENE INFORMATION
Gene name	GPR183 (HGNC Symbol)
Synonyms	EBI2
Description	G protein-coupled receptor 183 (HGNC Symbol)
Entrez gene summary	This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q32.3
Chromosome location (bp)	99294530 - 99307405
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169508 (version 83.38)
Entrez gene	1880
UniProt	P32249 (UniProt - Evidence at protein level)
neXtProt	NX_P32249
Antibodypedia	GPR183 antibodies

PROTEIN BROWSER

GPR183-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR183-001 ENSP00000365596 ENST00000376414	P32249 [Direct mapping] G-protein coupled receptor 183 A0A024RDX2 [Target identity:100%; Query identity:100%] Epstein-Barr virus induced gene 2 (Lymphocyte-specific G protein-coupled receptor), isoform CRA_a Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0002312 [B cell activation involved in immune response] GO:0002313 [mature B cell differentiation involved in immune response] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0006959 [humoral immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0008142 [oxysterol binding] GO:0016021 [integral component of membrane] GO:0030890 [positive regulation of B cell proliferation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	361 aa 41.2 kDa	No	7