Cell atlas - CCDC8 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CCDC8

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CCDC8
Gene description	Coiled-coil domain containing 8
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleus.
RNA cell category	Cell line enhanced (RH-30, AN3-CA, AF22, K-562)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041993
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RH-30, AN3-CA, AF22, K-562) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleus.

Main location

Plasma membrane (approved), Cytosol (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041993	A-431	Plasma membrane
	HPA041993	A-431	Cytosol
	HPA041993	U-2 OS	Plasma membrane
	HPA041993	U-2 OS	Cytosol
	HPA041993	U-251 MG	Nucleus
			Plasma membrane
			Cytosol

GENE INFORMATION
Gene name	CCDC8 (HGNC Symbol)
Synonyms	3M3, DKFZp564K0322, PPP1R20
Description	Coiled-coil domain containing 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). [provided by RefSeq, Dec 2011]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	46410372 - 46413584
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169515 (version 83.38)
Entrez gene	83987
UniProt	Q9H0W5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H0W5
Antibodypedia	CCDC8 antibodies

PROTEIN BROWSER

CCDC8-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC8-001 ENSP00000303158 ENST00000307522	Q9H0W5 [Direct mapping] Coiled-coil domain-containing protein 8 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane] GO:0007088 [regulation of mitotic nuclear division] GO:0010923 [negative regulation of phosphatase activity] GO:1990393 [3M complex] Show all	538 aa 59.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.