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ZEB2

CANCER ATLAS

Gene description

 Zinc finger E-box binding homeobox 2

Protein class

 Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA003456

GENE INFORMATION

Gene name

 ZEB2 (HGNC Symbol)

Synonyms

 KIAA0569, SIP-1, SIP1, ZFHX1B

Description

 Zinc finger E-box binding homeobox 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]

Chromosome

 2

Cytoband

 q22.3

Chromosome location (bp)

 144384081 - 144524583

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169554 (version 83.38)

Entrez gene

 9839

UniProt

 O60315 (UniProt - Evidence at protein level)

neXtProt

 NX_O60315

Antibodypedia

 ZEB2 antibodies

PROTEIN BROWSER
«
ZEB2-001
ZEB2-005
ZEB2-007
ZEB2-008
ZEB2-009
ZEB2-010
ZEB2-011
ZEB2-013
ZEB2-014
ZEB2-019
ZEB2-020
ZEB2-021
ZEB2-022
ZEB2-025
ZEB2-026
ZEB2-028
ZEB2-031
ZEB2-032
ZEB2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZEB2-001
ENSP00000487174
ENST00000627532
O60315 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001755 [neural crest cell migration]
GO:0001756 [somitogenesis]
GO:0001843 [neural tube closure]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007399 [nervous system development]
GO:0007417 [central nervous system development]
GO:0019208 [phosphatase regulator activity]
GO:0021766 [hippocampus development]
GO:0021846 [cell proliferation in forebrain]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045636 [positive regulation of melanocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048023 [positive regulation of melanin biosynthetic process]
GO:0048066 [developmental pigmentation]
GO:0048598 [embryonic morphogenesis]
GO:0070412 [R-SMAD binding]
GO:0097324 [melanocyte migration]
GO:1902748 [positive regulation of lens fiber cell differentiation]
GO:1903056 [regulation of melanosome organization]
Show all
 1214 aa
136.4 kDa 		No 0
ZEB2-005
ENSP00000475502
ENST00000465070
U3KQ33 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 58 aa
6.5 kDa 		No 0
ZEB2-007
ENSP00000376601
ENST00000392861
E7ESP8 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 467 aa
52.1 kDa 		No 0
ZEB2-008
ENSP00000454157
ENST00000558170
O60315 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007399 [nervous system development]
GO:0019208 [phosphatase regulator activity]
GO:0045636 [positive regulation of melanocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048023 [positive regulation of melanin biosynthetic process]
GO:0048066 [developmental pigmentation]
GO:0097324 [melanocyte migration]
GO:1903056 [regulation of melanosome organization]
Show all
 1214 aa
136.4 kDa 		No 0
ZEB2-009
ENSP00000475329
ENST00000470879
U3KPX6 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 87 aa
9.7 kDa 		No 0
ZEB2-010
ENSP00000395496
ENST00000427902
E7EUW9 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0046872 [metal ion binding]
Show all
 731 aa
81.9 kDa 		No 0
ZEB2-011
ENSP00000386854
ENST00000409487
O60315 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007399 [nervous system development]
GO:0019208 [phosphatase regulator activity]
GO:0045636 [positive regulation of melanocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048023 [positive regulation of melanin biosynthetic process]
GO:0048066 [developmental pigmentation]
GO:0097324 [melanocyte migration]
GO:1903056 [regulation of melanosome organization]
Show all
 1214 aa
136.4 kDa 		No 0
ZEB2-013
ENSP00000394777
ENST00000419938
H7C0G0 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 220 aa
25.1 kDa 		No 0
ZEB2-014
ENSP00000399451
ENST00000444559
C9JUQ1 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 63 aa
7.1 kDa 		No 0
ZEB2-019
ENSP00000487476
ENST00000465308
A0A0D9SGG5 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 142 aa
15.8 kDa 		No 0
ZEB2-020
ENSP00000486240
ENST00000629520
U3KQ33 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 58 aa
6.5 kDa 		No 0
ZEB2-021
ENSP00000400993
ENST00000435831
C9JU62 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 91 aa
10.2 kDa 		No 0
ZEB2-022
ENSP00000475400
ENST00000462355
U3KQ33 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 58 aa
6.5 kDa 		No 0
ZEB2-025
ENSP00000443792
ENST00000539609
O60315 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007399 [nervous system development]
GO:0019208 [phosphatase regulator activity]
GO:0045636 [positive regulation of melanocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048023 [positive regulation of melanin biosynthetic process]
GO:0048066 [developmental pigmentation]
GO:0097324 [melanocyte migration]
GO:1903056 [regulation of melanosome organization]
Show all
 1190 aa
133.8 kDa 		No 0
ZEB2-026
ENSP00000302501
ENST00000303660
A0JP08 [Target identity:100%; Query identity:100%]
Zinc finger E-box binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0046872 [metal ion binding]
Show all
 1213 aa
136.3 kDa 		No 0
ZEB2-028
ENSP00000387256
ENST00000409211
E7EVG9 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 120 aa
13.4 kDa 		No 0
ZEB2-031
ENSP00000486346
ENST00000630572
A0A0D9SF74 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 39 aa
4.5 kDa 		No 0
ZEB2-032
ENSP00000475267
ENST00000431672
U3KPV5 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 184 aa
20.6 kDa 		No 0
ZEB2-201
ENSP00000475553
ENST00000440875
U3KQ51 [Direct mapping]
Zinc finger E-box-binding homeobox 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 423 aa
47.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.