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Malignant cells generally showed weak to moderate cytoplasmic and/or nuclear staining. Cases of pancreatic and renal cancers were strongly stained.
GENE INFORMATION
Gene name
HINT1 (HGNC Symbol)
Synonyms
HINT, PKCI-1, PRKCNH1
Description
Histidine triad nucleotide binding protein 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]