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CLIC3

GENERAL INFORMATION

Gene name

 CLIC3

Gene description

 Chloride intracellular channel 3

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus, thyroid gland)
GTEx:Tissue enhanced (esophagus, thyroid gland, vagina)
FANTOM5:Group enriched (placenta, esophagus, thyroid gland, tonsil, lung, cervix, uterine)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in several tissues, highly abundant in thyroid gland and placenta.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA005963
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, thyroid gland, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (placenta, esophagus, thyroid gland, tonsil, lung, cervix, uterine)

GENE INFORMATION

Gene name

 CLIC3

Synonyms

Description

 Chloride intracellular channel 3 (HGNC Symbol)

Entrez gene summary

 Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 136994635 - 136996803

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169583 (version 83.38)

Entrez gene

 9022

UniProt

 O95833 (UniProt - Evidence at protein level)

neXtProt

 NX_O95833

Antibodypedia

 CLIC3 antibodies

PROTEIN BROWSER
CLIC3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLIC3-001
ENSP00000419378
ENST00000494426
O95833 [Direct mapping]
Chloride intracellular channel protein 3
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006821 [chloride transport]
GO:0007165 [signal transduction]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1902476 [chloride transmembrane transport]
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 236 aa
26.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.