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Most cancer tissues showed moderate nuclear with occasional cytoplasmic positivity. Several pancreatic cancers along with a few liver and breast cancers exhibited strong immunoreactivity. A majority of lymphomas, skin, prostate and stomach cancers were weakly stained or negative.
GENE INFORMATION
Gene name
NFU1 (HGNC Symbol)
Synonyms
CGI-33, HIRIP5, NifU, NIFUC
Description
NFU1 iron-sulfur cluster scaffold (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]