Tissue expression of ANTXR1 - Summary - The Human Protein Atlas

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ANTXR1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ANTXR1
Gene description	Anthrax toxin receptor 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Shows cytoplasmic expression in endothelial cells and positivity in plasma.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 1 antibody. HPA052046
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ANTXR1 (HGNC Symbol)
Synonyms	ATR, FLJ10601, FLJ21776, TEM8
Description	Anthrax toxin receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	69013178 - 69249327
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169604 (version 83.38)
Entrez gene	84168
UniProt	Q9H6X2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6X2
Antibodypedia	ANTXR1 antibodies

PROTEIN BROWSER

ANTXR1-001	ANTXR1-002	ANTXR1-003	ANTXR1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANTXR1-001 ENSP00000301945 ENST00000303714	Q9H6X2 [Direct mapping] Anthrax toxin receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0022414 [reproductive process] GO:0031258 [lamellipodium membrane] GO:0031527 [filopodium membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0046872 [metal ion binding] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	564 aa 62.8 kDa	Yes	1
ANTXR1-002 ENSP00000386494 ENST00000409349	Q9H6X2 [Direct mapping] Anthrax toxin receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0031258 [lamellipodium membrane] GO:0031527 [filopodium membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0046872 [metal ion binding] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	368 aa 41.2 kDa	Yes	1
ANTXR1-003 ENSP00000387058 ENST00000409829	Q9H6X2 [Direct mapping] Anthrax toxin receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0031258 [lamellipodium membrane] GO:0031527 [filopodium membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0046872 [metal ion binding] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	333 aa 37.1 kDa	Yes	0
ANTXR1-005 ENSP00000430776 ENST00000482235	H0YC24 [Direct mapping] Anthrax toxin receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0016021 [integral component of membrane] Show all	179 aa 19.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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