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LIMS1

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GENERAL INFORMATION

Gene name

 LIMS1

Gene description

 LIM and senescent cell antigen-like domains 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the focal adhesion sites. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Focal adhesion sites (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA058455
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the focal adhesion sites. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Cytosol (supported)

Additional location

 Focal adhesion sites (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA058455 U-251 MG Focal adhesion sites
Cytosol

GENE INFORMATION

Gene name

 LIMS1 (HGNC Symbol)

Synonyms

 PINCH, PINCH1

Description

 LIM and senescent cell antigen-like domains 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Chromosome

 2

Cytoband

 q12.3

Chromosome location (bp)

 108534355 - 108687246

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169756 (version 83.38)

Entrez gene

 3987

UniProt

 P48059 (UniProt - Evidence at protein level)

neXtProt

 NX_P48059

Antibodypedia

 LIMS1 antibodies

PROTEIN BROWSER
LIMS1-001
LIMS1-002
LIMS1-003
LIMS1-005
LIMS1-006
LIMS1-007
LIMS1-011
LIMS1-012
LIMS1-014
LIMS1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIMS1-001
ENSP00000376987
ENST00000393310
P48059 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007569 [cell aging]
GO:0008270 [zinc ion binding]
GO:0010628 [positive regulation of gene expression]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0019901 [protein kinase binding]
GO:0034329 [cell junction assembly]
GO:0043547 [positive regulation of GTPase activity]
GO:0045184 [establishment of protein localization]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
 325 aa
37.3 kDa 		No 0
LIMS1-002
ENSP00000331775
ENST00000332345
P48059 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007569 [cell aging]
GO:0008270 [zinc ion binding]
GO:0010628 [positive regulation of gene expression]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0019901 [protein kinase binding]
GO:0034329 [cell junction assembly]
GO:0043547 [positive regulation of GTPase activity]
GO:0045184 [establishment of protein localization]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
 325 aa
37.3 kDa 		No 0
LIMS1-003
ENSP00000387264
ENST00000409441
P48059 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007569 [cell aging]
GO:0008270 [zinc ion binding]
GO:0010628 [positive regulation of gene expression]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0019901 [protein kinase binding]
GO:0034329 [cell junction assembly]
GO:0043547 [positive regulation of GTPase activity]
GO:0045184 [establishment of protein localization]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
 362 aa
41.6 kDa 		No 0
LIMS1-005
ENSP00000399267
ENST00000414829
F8WC86 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 117 aa
13.3 kDa 		No 0
LIMS1-006
ENSP00000386926
ENST00000410093
P48059 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007569 [cell aging]
GO:0008270 [zinc ion binding]
GO:0010628 [positive regulation of gene expression]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0019901 [protein kinase binding]
GO:0034329 [cell junction assembly]
GO:0043547 [positive regulation of GTPase activity]
GO:0045184 [establishment of protein localization]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
 329 aa
37.7 kDa 		No 0
LIMS1-007
ENSP00000390862
ENST00000428064
C9JF46 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 177 aa
20 kDa 		No 0
LIMS1-011
ENSP00000410751
ENST00000434274
F8WB59 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 55 aa
6.1 kDa 		No 0
LIMS1-012
ENSP00000446121
ENST00000542845
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 209 aa
24.3 kDa 		No 0
LIMS1-014
ENSP00000337598
ENST00000338045
P48059 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007569 [cell aging]
GO:0008270 [zinc ion binding]
GO:0010628 [positive regulation of gene expression]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0019901 [protein kinase binding]
GO:0034329 [cell junction assembly]
GO:0043547 [positive regulation of GTPase activity]
GO:0045184 [establishment of protein localization]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
 387 aa
44.4 kDa 		No 0
LIMS1-201
ENSP00000437912
ENST00000544547
P48059 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007569 [cell aging]
GO:0008270 [zinc ion binding]
GO:0010628 [positive regulation of gene expression]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0019901 [protein kinase binding]
GO:0034329 [cell junction assembly]
GO:0043547 [positive regulation of GTPase activity]
GO:0045184 [establishment of protein localization]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
 337 aa
38.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.