Cell atlas - GUSB - The Human Protein Atlas

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GUSB

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	GUSB
Gene description	Glucuronidase, beta
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA036322
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036322	A-431	Vesicles
	HPA036322	U-2 OS	Vesicles	Intensity

GENE INFORMATION
Gene name	GUSB
Synonyms
Description	Glucuronidase, beta (HGNC Symbol)
Entrez gene summary	This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]
Chromosome	7
Cytoband	q11.21
Chromosome location (bp)	65960684 - 65982314
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169919 (version 83.38)
Entrez gene	2990
UniProt	P08236 (UniProt - Evidence at protein level)
neXtProt	NX_P08236
Antibodypedia	GUSB antibodies

PROTEIN BROWSER

GUSB-001	GUSB-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GUSB-001 ENSP00000302728 ENST00000304895	P08236 [Direct mapping] Beta-glucuronidase Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004566 [beta-glucuronidase activity] GO:0005102 [receptor binding] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005975 [carbohydrate metabolic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0016020 [membrane] GO:0019391 [glucuronoside catabolic process] GO:0019904 [protein domain specific binding] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0043202 [lysosomal lumen] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	651 aa 74.7 kDa	Yes	0
GUSB-002 ENSP00000391390 ENST00000421103	P08236 [Direct mapping] Beta-glucuronidase Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004566 [beta-glucuronidase activity] GO:0005102 [receptor binding] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0016020 [membrane] GO:0019391 [glucuronoside catabolic process] GO:0019904 [protein domain specific binding] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0043202 [lysosomal lumen] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	505 aa 58.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.