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FRMPD4

GENERAL INFORMATION

Gene name

 FRMPD4

Gene description

 FERM and PDZ domain containing 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (parathyroid gland, cerebral cortex)
GTEx:Group enriched (cerebral cortex, caudate, hippocampus, cerebellum, hypothalamus)
FANTOM5:Tissue enhanced (hippocampus, caudate, brain)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in CNS and parathyroid gland.

DATA RELIABILITY

Data reliability
description

 Pending external verification. Presumed off target binding observed and disregarded. Pending retesting.

Reliability score

 Uncertain based on 1 antibody.
HPA035580
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (parathyroid gland, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, caudate, hippocampus, cerebellum, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hippocampus, caudate, brain)

GENE INFORMATION

Gene name

 FRMPD4 (HGNC Symbol)

Synonyms

 KIAA0316, PDZD10, PDZK10

Description

 FERM and PDZ domain containing 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. [provided by RefSeq, Jan 2010]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 12138466 - 12724523

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169933 (version 83.38)

Entrez gene

 9758

UniProt

 Q14CM0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14CM0

Antibodypedia

 FRMPD4 antibodies

PROTEIN BROWSER
FRMPD4-001
FRMPD4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FRMPD4-001
ENSP00000370057
ENST00000380682
Q14CM0 [Direct mapping]
FERM and PDZ domain-containing protein 4
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005856 [cytoskeleton]
GO:0043197 [dendritic spine]
GO:0051835 [positive regulation of synapse structural plasticity]
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 1322 aa
144.4 kDa 		No 0
FRMPD4-201
ENSP00000482182
ENST00000616992
A0A087WYX8 [Direct mapping]
FERM and PDZ domain-containing protein 4
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Predicted intracellular proteins
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GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
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 1282 aa
140 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.