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ZFPM2

GENERAL INFORMATION

Gene name

 ZFPM2

Gene description

 Zinc finger protein, FOG family member 2

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (ovary)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA004094
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ZFPM2 (HGNC Symbol)

Synonyms

 FOG2, hFOG-2, ZC2HC11B, ZNF89B

Description

 Zinc finger protein, FOG family member 2 (HGNC Symbol)

Entrez gene summary

 The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

Chromosome location (bp)

 104590733 - 105804532

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169946 (version 83.38)

Entrez gene

 23414

UniProt

 Q8WW38 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WW38

Antibodypedia

 ZFPM2 antibodies

PROTEIN BROWSER
ZFPM2-001
ZFPM2-002
ZFPM2-004
ZFPM2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZFPM2-001
ENSP00000430757
ENST00000520492
E7ET52 [Direct mapping]
Zinc finger protein ZFPM2
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Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0007507 [heart development]
GO:0030154 [cell differentiation]
GO:0046872 [metal ion binding]
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 1019 aa
113.3 kDa 		No 0
ZFPM2-002
ENSP00000384179
ENST00000407775
Q8WW38 [Direct mapping]
Zinc finger protein ZFPM2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0001570 [vasculogenesis]
GO:0001701 [in utero embryonic development]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003221 [right ventricular cardiac muscle tissue morphogenesis]
GO:0003677 [DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007506 [gonadal mesoderm development]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048738 [cardiac muscle tissue development]
GO:0060412 [ventricular septum morphogenesis]
GO:0060548 [negative regulation of cell death]
GO:2000020 [positive regulation of male gonad development]
GO:2000195 [negative regulation of female gonad development]
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 1151 aa
128.2 kDa 		No 0
ZFPM2-004
ENSP00000428720
ENST00000517361
E7ET52 [Direct mapping]
Zinc finger protein ZFPM2
Show all
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0007507 [heart development]
GO:0030154 [cell differentiation]
GO:0046872 [metal ion binding]
Show all
 1019 aa
113.3 kDa 		No 0
ZFPM2-005
ENSP00000428149
ENST00000520027
E5RJX0 [Direct mapping]
Zinc finger protein ZFPM2
Show all
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0005634 [nucleus]
GO:0007507 [heart development]
GO:0030154 [cell differentiation]
Show all
 26 aa
2.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.