Expression of UBE2E3 in cancer - Summary

CANCER ATLAS

Gene description

Ubiquitin-conjugating enzyme E2E 3

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA003303	HPA030445

GENE INFORMATION
Gene name	UBE2E3 (HGNC Symbol)
Synonyms	UbcH9
Description	Ubiquitin-conjugating enzyme E2E 3 (HGNC Symbol)
Entrez gene summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]
Chromosome	2
Cytoband	q31.3
Chromosome location (bp)	180967248 - 181076585
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170035 (version 83.38)
Entrez gene	10477
UniProt	Q969T4 (UniProt - Evidence at protein level)
neXtProt	NX_Q969T4
Antibodypedia	UBE2E3 antibodies

PROTEIN BROWSER

UBE2E3-001	UBE2E3-002	UBE2E3-003	UBE2E3-004	UBE2E3-005	UBE2E3-006	UBE2E3-007	UBE2E3-008	UBE2E3-012	UBE2E3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBE2E3-001 ENSP00000386788 ENST00000410062	Q969T4 [Direct mapping] Ubiquitin-conjugating enzyme E2 E3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0040008 [regulation of growth] GO:0061631 [ubiquitin conjugating enzyme activity] GO:0070534 [protein K63-linked ubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] Show all	207 aa 22.9 kDa	No	0
UBE2E3-002 ENSP00000473623 ENST00000602710	Q969T4 [Direct mapping] Ubiquitin-conjugating enzyme E2 E3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0040008 [regulation of growth] GO:0070534 [protein K63-linked ubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] Show all	207 aa 22.9 kDa	No	0
UBE2E3-003 ENSP00000473639 ENST00000602959	Q969T4 [Direct mapping] Ubiquitin-conjugating enzyme E2 E3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0040008 [regulation of growth] GO:0070534 [protein K63-linked ubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] Show all	207 aa 22.9 kDa	No	0
UBE2E3-004 ENSP00000473345 ENST00000602479	R4GND1 [Direct mapping] Ubiquitin-conjugating enzyme E2 E3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	175 aa 19.2 kDa	No	0
UBE2E3-005 ENSP00000473264 ENST00000602475	R4GMM6 [Direct mapping] Ubiquitin-conjugating enzyme E2 E3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 12.2 kDa	No	0
UBE2E3-006 ENSP00000473521 ENST00000602499	R4GN77 [Direct mapping] Ubiquitin-conjugating enzyme E2 E3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13.4 kDa	No	0
UBE2E3-007 ENSP00000473525 ENST00000602303	R4GND1 [Direct mapping] Ubiquitin-conjugating enzyme E2 E3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	175 aa 19.2 kDa	No	0
UBE2E3-008 ENSP00000473642 ENST00000602632	R4GNG6 [Direct mapping] Ubiquitin-conjugating enzyme E2 E3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 14.1 kDa	No	0
UBE2E3-012 ENSP00000473591 ENST00000602291	R4GND1 [Direct mapping] Ubiquitin-conjugating enzyme E2 E3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	175 aa 19.2 kDa	No	0
UBE2E3-201 ENSP00000376215 ENST00000392415	Q969T4 [Direct mapping] Ubiquitin-conjugating enzyme E2 E3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0040008 [regulation of growth] GO:0070534 [protein K63-linked ubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] Show all	207 aa 22.9 kDa	No	0