Cell atlas - FOXD4 - The Human Protein Atlas

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FOXD4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FOXD4
Gene description	Forkhead box D4
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (THP-1)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA012836
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (THP-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA012836	A-431	Nucleus
	HPA012836	U-2 OS	Nucleus
	HPA012836	U-251 MG	Nucleus

GENE INFORMATION
Gene name	FOXD4 (HGNC Symbol)
Synonyms	FKHL9, FOXD4a, FREAC5
Description	Forkhead box D4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012]
Chromosome	9
Cytoband	p24.3
Chromosome location (bp)	116231 - 118204
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000170122 (version 83.38)
Entrez gene	2298
UniProt	Q12950 (UniProt - Evidence at transcript level)
neXtProt	NX_Q12950
Antibodypedia	FOXD4 antibodies

PROTEIN BROWSER

FOXD4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOXD4-001 ENSP00000371940 ENST00000382500	Q12950 [Direct mapping] Forkhead box protein D4 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008301 [DNA binding, bending] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] Show all	439 aa 47.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.