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CHRNB1

CANCER ATLAS

Gene description

 Cholinergic receptor, nicotinic, beta 1 (muscle)

Protein class

 Disease related genes, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005822
CAB011200

GENE INFORMATION

Gene name

 CHRNB1 (HGNC Symbol)

Synonyms

 CHRNB

Description

 Cholinergic receptor, nicotinic, beta 1 (muscle) (HGNC Symbol)

Entrez gene summary

 The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7445061 - 7457707

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170175 (version 83.38)

Entrez gene

 1140

UniProt

 P11230 (UniProt - Evidence at protein level)

neXtProt

 NX_P11230

Antibodypedia

 CHRNB1 antibodies

PROTEIN BROWSER
CHRNB1-001
CHRNB1-002
CHRNB1-004
CHRNB1-006
CHRNB1-007
CHRNB1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHRNB1-001
ENSP00000304290
ENST00000306071
P11230 [Direct mapping]
Acetylcholine receptor subunit beta
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001941 [postsynaptic membrane organization]
GO:0003009 [skeletal muscle contraction]
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005892 [acetylcholine-gated channel complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007274 [neuromuscular synaptic transmission]
GO:0015267 [channel activity]
GO:0015276 [ligand-gated ion channel activity]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0035095 [behavioral response to nicotine]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0048747 [muscle fiber development]
GO:0050877 [neurological system process]
GO:0098655 [cation transmembrane transport]
Show all
 501 aa
56.7 kDa 		Yes 4
CHRNB1-002
ENSP00000439209
ENST00000536404
P11230 [Direct mapping]
Acetylcholine receptor subunit beta
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001941 [postsynaptic membrane organization]
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0005892 [acetylcholine-gated channel complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007274 [neuromuscular synaptic transmission]
GO:0015267 [channel activity]
GO:0015276 [ligand-gated ion channel activity]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0035095 [behavioral response to nicotine]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0048747 [muscle fiber development]
GO:0050877 [neurological system process]
GO:0098655 [cation transmembrane transport]
Show all
 429 aa
49.1 kDa 		No 4
CHRNB1-004
ENSP00000461402
ENST00000572857
I3L4N5 [Direct mapping]
Acetylcholine receptor subunit beta
Show all
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0045211 [postsynaptic membrane]
GO:0098655 [cation transmembrane transport]
Show all
 158 aa
16.8 kDa 		Yes 0
CHRNB1-006
ENSP00000459092
ENST00000576360
I3L1T7 [Direct mapping]
Acetylcholine receptor subunit beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0045211 [postsynaptic membrane]
GO:0098655 [cation transmembrane transport]
Show all
 380 aa
43.7 kDa 		No 2
CHRNB1-007
ENSP00000460648
ENST00000570557
I3L3Q9 [Direct mapping]
Acetylcholine receptor subunit beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0045211 [postsynaptic membrane]
GO:0098655 [cation transmembrane transport]
Show all
 316 aa
35.7 kDa 		No 2
CHRNB1-008
ENSP00000461751
ENST00000575379
I3L535 [Direct mapping]
Acetylcholine receptor subunit beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 37 aa
4.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.