Tissue expression of SLC16A5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC16A5
Gene description	Solute carrier family 16 (monocarboxylate transporter), member 5
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (kidney)
FANTOM5:	Mixed

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	SLC16A5 (HGNC Symbol)
Synonyms	MCT5, MCT6
Description	Solute carrier family 16 (monocarboxylate transporter), member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	75087727 - 75106162
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000170190 (version 83.38)
Entrez gene	9121
UniProt	O15375 (UniProt - Evidence at transcript level)
neXtProt	NX_O15375
Antibodypedia	SLC16A5 antibodies

PROTEIN BROWSER

SLC16A5-001	SLC16A5-002	SLC16A5-003	SLC16A5-004	SLC16A5-005	SLC16A5-006	SLC16A5-007	SLC16A5-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC16A5-001 ENSP00000463434 ENST00000580123	O15375 [Direct mapping] Monocarboxylate transporter 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	505 aa 55 kDa	No	>9
SLC16A5-002 ENSP00000330141 ENST00000329783	O15375 [Direct mapping] Monocarboxylate transporter 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	505 aa 55 kDa	No	>9
SLC16A5-003 ENSP00000463363 ENST00000578376	J3QL40 [Direct mapping] Monocarboxylate transporter 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	454 aa 49.3 kDa	No	>9
SLC16A5-004 ENSP00000390564 ENST00000450736	O15375 [Direct mapping] Monocarboxylate transporter 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	505 aa 55 kDa	No	>9
SLC16A5-005 ENSP00000440212 ENST00000538213	O15375 [Direct mapping] Monocarboxylate transporter 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	500 aa 54.4 kDa	No	>9
SLC16A5-006 ENSP00000462866 ENST00000578847	J3KT93 [Direct mapping] Monocarboxylate transporter 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] Show all	53 aa 5.9 kDa	No	1
SLC16A5-007 ENSP00000462267 ENST00000584207	J3KS19 [Direct mapping] Monocarboxylate transporter 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	203 aa 22.2 kDa	No	5
SLC16A5-008 ENSP00000463931 ENST00000584118	J3QQW5 [Direct mapping] Monocarboxylate transporter 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	236 aa 25.6 kDa	No	6