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CRTAP

GENERAL INFORMATION

Gene name

 CRTAP

Gene description

 Cartilage associated protein

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA043598 , HPA044150
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CRTAP (HGNC Symbol)

Synonyms

 CASP, LEPREL3, P3H5

Description

 Cartilage associated protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p22.3

Chromosome location (bp)

 33113979 - 33147773

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170275 (version 83.38)

Entrez gene

 10491

UniProt

 O75718 (UniProt - Evidence at protein level)

neXtProt

 NX_O75718

Antibodypedia

 CRTAP antibodies

PROTEIN BROWSER
CRTAP-001
CRTAP-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRTAP-001
ENSP00000323696
ENST00000320954
O75718 [Direct mapping]
Cartilage-associated protein
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007283 [spermatogenesis]
GO:0018400 [peptidyl-proline hydroxylation to 3-hydroxy-L-proline]
GO:0030198 [extracellular matrix organization]
GO:0032403 [protein complex binding]
GO:0032991 [macromolecular complex]
GO:0050821 [protein stabilization]
GO:0061077 [chaperone-mediated protein folding]
GO:1901874 [negative regulation of post-translational protein modification]
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 401 aa
46.6 kDa 		Yes 0
CRTAP-003
ENSP00000409997
ENST00000449224
C9JP16 [Direct mapping]
Cartilage-associated protein
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 358 aa
41.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.