Cell atlas - SLN - The Human Protein Atlas

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SLN

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	SLN
Gene description	Sarcolipin
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules.
RNA cell category	Cell line enhanced (U-2 OS, BEWO, PC-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB011628
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2 OS, BEWO, PC-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules.

Main location

Microtubules (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB011628	A-431	Microtubules
	CAB011628	U-2 OS	Microtubules

GENE INFORMATION
Gene name	SLN (HGNC Symbol)
Synonyms	MGC12301, MGC125854, MGC125855
Description	Sarcolipin (HGNC Symbol)
Entrez gene summary	Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q22.3
Chromosome location (bp)	107707378 - 107719693
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170290 (version 83.38)
Entrez gene	6588
UniProt	O00631 (UniProt - Evidence at protein level)
neXtProt	NX_O00631
Antibodypedia	SLN antibodies

PROTEIN BROWSER

SLN-001	SLN-002	SLN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLN-001 ENSP00000435380 ENST00000531293	O00631 [Direct mapping] Sarcolipin Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004857 [enzyme inhibitor activity] GO:0005515 [protein binding] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0030234 [enzyme regulator activity] GO:0033017 [sarcoplasmic reticulum membrane] GO:0043086 [negative regulation of catalytic activity] GO:0043242 [negative regulation of protein complex disassembly] GO:0051117 [ATPase binding] GO:0051924 [regulation of calcium ion transport] GO:0070296 [sarcoplasmic reticulum calcium ion transport] GO:0090281 [negative regulation of calcium ion import] GO:1901020 [negative regulation of calcium ion transmembrane transporter activity] GO:1901077 [regulation of relaxation of muscle] GO:1901877 [negative regulation of calcium ion binding] GO:1901881 [positive regulation of protein depolymerization] GO:1901894 [regulation of calcium-transporting ATPase activity] Show all	31 aa 3.8 kDa	No	1
SLN-002 ENSP00000434189 ENST00000525934	O00631 [Direct mapping] Sarcolipin Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004857 [enzyme inhibitor activity] GO:0005515 [protein binding] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0030234 [enzyme regulator activity] GO:0033017 [sarcoplasmic reticulum membrane] GO:0043086 [negative regulation of catalytic activity] GO:0043242 [negative regulation of protein complex disassembly] GO:0051117 [ATPase binding] GO:0051924 [regulation of calcium ion transport] GO:0070296 [sarcoplasmic reticulum calcium ion transport] GO:0090281 [negative regulation of calcium ion import] GO:1901020 [negative regulation of calcium ion transmembrane transporter activity] GO:1901077 [regulation of relaxation of muscle] GO:1901877 [negative regulation of calcium ion binding] GO:1901881 [positive regulation of protein depolymerization] GO:1901894 [regulation of calcium-transporting ATPase activity] Show all	31 aa 3.8 kDa	No	1
SLN-201 ENSP00000304707 ENST00000305991	O00631 [Direct mapping] Sarcolipin Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004857 [enzyme inhibitor activity] GO:0005515 [protein binding] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0030234 [enzyme regulator activity] GO:0033017 [sarcoplasmic reticulum membrane] GO:0043086 [negative regulation of catalytic activity] GO:0043242 [negative regulation of protein complex disassembly] GO:0051117 [ATPase binding] GO:0051924 [regulation of calcium ion transport] GO:0070296 [sarcoplasmic reticulum calcium ion transport] GO:0090281 [negative regulation of calcium ion import] GO:1901020 [negative regulation of calcium ion transmembrane transporter activity] GO:1901077 [regulation of relaxation of muscle] GO:1901877 [negative regulation of calcium ion binding] GO:1901881 [positive regulation of protein depolymerization] GO:1901894 [regulation of calcium-transporting ATPase activity] Show all	31 aa 3.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.