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Malignant tissues displayed weak to moderate cytoplasmic and occasional nuclear positivity. Several cases of malignant melanomas, testicular, prostate and breast cancers were negative.
Fraction of cells in several cases of malignant gliomas, malignant lymphomas along with few cases of colorectal, endometrial, cervical, ovarian, pancreatic and prostate cancers showed moderate to strong cytoplasmic and nuclear positivity. Remaining cancer tissues were weakly stained or negative.
This gene was initially thought to represent a pseudogene of galectin 9; however, this transcript has good exon-intron structure and encodes a predicted protein of the same size as and highly similar to galectin 9. This gene is one of two similar loci on chromosome 17p similar to galectin 9 and now thought to be protein-encoding. This gene is the more centromeric gene. [provided by RefSeq, Jul 2008]
