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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

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Score

Score

Antibodies

Column

 
 
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CDK1
  • TISSUE

  • premium

    CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Cyclin-dependent kinase 1

Protein class

Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY

HPA003387
CAB003799

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed weak to moderate nuclear and cytoplasmic immunoreactivity. Cases of breast cancer showed strong positivity in a fraction of cells. Renal and liver cancers were negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer tissues showed moderate to strong nuclear immunoreactivity, often accompanied with cytoplasmic staining. Prostate cancers and basal cell carcinomas showed positivity in a smaller fraction of the cells.

GENE INFORMATION

Gene name

CDK1 (HGNC Symbol)

Synonyms

CDC2, CDC28A

Description

Cyclin-dependent kinase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

10

Cytoband

q21.2

Chromosome location (bp)

60778331 - 60794852

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170312 (version 83.38)

Entrez gene

983

UniProt

P06493 (UniProt - Evidence at protein level)

neXtProt

NX_P06493

Antibodypedia

CDK1 antibodies

PROTEIN BROWSER

CDK1-007
CDK1-008
CDK1-009
CDK1-013
CDK1-201
CDK1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK1-007
ENSP00000378699
ENST00000395284
P06493 [Direct mapping]
Cyclin-dependent kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000187 [activation of MAPK activity]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006461 [protein complex assembly]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007098 [centrosome cycle]
GO:0007344 [pronuclear fusion]
GO:0007569 [cell aging]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0009636 [response to toxic substance]
GO:0010243 [response to organonitrogen compound]
GO:0010628 [positive regulation of gene expression]
GO:0014038 [regulation of Schwann cell differentiation]
GO:0014070 [response to organic cyclic compound]
GO:0014075 [response to amine]
GO:0014823 [response to activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016477 [cell migration]
GO:0016572 [histone phosphorylation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030261 [chromosome condensation]
GO:0030332 [cyclin binding]
GO:0030496 [midbody]
GO:0030544 [Hsp70 protein binding]
GO:0030855 [epithelial cell differentiation]
GO:0031100 [organ regeneration]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0034501 [protein localization to kinetochore]
GO:0035173 [histone kinase activity]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0043066 [negative regulation of apoptotic process]
GO:0045471 [response to ethanol]
GO:0045740 [positive regulation of DNA replication]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045995 [regulation of embryonic development]
GO:0046686 [response to cadmium ion]
GO:0046688 [response to copper ion]
GO:0048678 [response to axon injury]
GO:0051301 [cell division]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0055015 [ventricular cardiac muscle cell development]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0072686 [mitotic spindle]
GO:0090166 [Golgi disassembly]
GO:1900182 [positive regulation of protein localization to nucleus]
Show all
297 aa
34.1 kDa
No 0
CDK1-008
ENSP00000362915
ENST00000373809
P06493 [Direct mapping]
Cyclin-dependent kinase 1
A0A024QZJ8 [Target identity:100%; Query identity:100%]
Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000187 [activation of MAPK activity]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007098 [centrosome cycle]
GO:0007344 [pronuclear fusion]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0014038 [regulation of Schwann cell differentiation]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016572 [histone phosphorylation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030496 [midbody]
GO:0030855 [epithelial cell differentiation]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0034501 [protein localization to kinetochore]
GO:0035173 [histone kinase activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045995 [regulation of embryonic development]
GO:0051301 [cell division]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090166 [Golgi disassembly]
GO:1900182 [positive regulation of protein localization to nucleus]
Show all
240 aa
27.5 kDa
No 0
CDK1-009
ENSP00000397973
ENST00000448257
A0A024QZP7 [Direct mapping]
Cell division cycle 2, G1 to S and G2 to M, isoform CRA_a; Cyclin-dependent kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0051301 [cell division]
Show all
297 aa
34.1 kDa
No 0
CDK1-013
ENSP00000430665
ENST00000519078
E5RIU6 [Direct mapping]
Cyclin-dependent kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
189 aa
21.7 kDa
No 0
CDK1-201
ENSP00000325970
ENST00000316629
P06493 [Direct mapping]
Cyclin-dependent kinase 1
A0A024QZJ8 [Target identity:100%; Query identity:100%]
Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000187 [activation of MAPK activity]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007098 [centrosome cycle]
GO:0007344 [pronuclear fusion]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0014038 [regulation of Schwann cell differentiation]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016572 [histone phosphorylation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030496 [midbody]
GO:0030855 [epithelial cell differentiation]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0034501 [protein localization to kinetochore]
GO:0035173 [histone kinase activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045995 [regulation of embryonic development]
GO:0051301 [cell division]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090166 [Golgi disassembly]
GO:1900182 [positive regulation of protein localization to nucleus]
Show all
240 aa
27.5 kDa
No 0
CDK1-202
ENSP00000482996
ENST00000614696
A0A087WZZ9 [Direct mapping]
Cyclin-dependent kinase 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
224 aa
25.8 kDa
No 0

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