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Weak to moderate nuclear positivity was observed in most cancer tissues. A majority of urothelial cancer tissues as well as a several cervical, skin and pancreatic cancer tissues were strongly stained. Lymphomas were negative.
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001661 [conditioned taste aversion] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006306 [DNA methylation] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007399 [nervous system development] GO:0007565 [female pregnancy] GO:0007568 [aging] GO:0008134 [transcription factor binding] GO:0009409 [response to cold] GO:0009416 [response to light stimulus] GO:0009612 [response to mechanical stimulus] GO:0009629 [response to gravity] GO:0009636 [response to toxic substance] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0030431 [sleep] GO:0031668 [cellular response to extracellular stimulus] GO:0032496 [response to lipopolysaccharide] GO:0032570 [response to progesterone] GO:0032870 [cellular response to hormone stimulus] GO:0034097 [response to cytokine] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0034614 [cellular response to reactive oxygen species] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035902 [response to immobilization stress] GO:0035914 [skeletal muscle cell differentiation] GO:0035994 [response to muscle stretch] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042493 [response to drug] GO:0043005 [neuron projection] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045672 [positive regulation of osteoclast differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0051412 [response to corticosterone] GO:0051591 [response to cAMP] GO:0060395 [SMAD protein signal transduction] GO:0070412 [R-SMAD binding] GO:0071277 [cellular response to calcium ion] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006306 [DNA methylation] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008134 [transcription factor binding] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0034614 [cellular response to reactive oxygen species] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0060395 [SMAD protein signal transduction] GO:0070412 [R-SMAD binding] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006306 [DNA methylation] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008134 [transcription factor binding] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0034614 [cellular response to reactive oxygen species] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0060395 [SMAD protein signal transduction] GO:0070412 [R-SMAD binding] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005667 [transcription factor complex] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005667 [transcription factor complex] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005667 [transcription factor complex] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding]