Cell atlas - SP7 - The Human Protein Atlas

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SP7

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SP7
Gene description	Sp7 transcription factor
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SP7 (HGNC Symbol)
Synonyms	osterix, OSX
Description	Sp7 transcription factor (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	53326575 - 53345315
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170374 (version 83.38)
Entrez gene	121340
UniProt	Q8TDD2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDD2
Antibodypedia	SP7 antibodies

PROTEIN BROWSER

SP7-001	SP7-002	SP7-003	SP7-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SP7-001 ENSP00000443827 ENST00000536324	Q8TDD2 [Direct mapping] Transcription factor Sp7 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0017151 [DEAD/H-box RNA helicase binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0060218 [hematopoietic stem cell differentiation] GO:2000738 [positive regulation of stem cell differentiation] Show all	431 aa 45 kDa	No	0
SP7-002 ENSP00000302812 ENST00000303846	Q8TDD2 [Direct mapping] Transcription factor Sp7 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0017151 [DEAD/H-box RNA helicase binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0060218 [hematopoietic stem cell differentiation] GO:2000738 [positive regulation of stem cell differentiation] Show all	431 aa 45 kDa	No	0
SP7-003 ENSP00000441367 ENST00000537210	Q8TDD2 [Direct mapping] Transcription factor Sp7 A0A024RAY8 [Target identity:100%; Query identity:100%] Sp7 transcription factor, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0001649 [osteoblast differentiation] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0017151 [DEAD/H-box RNA helicase binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0060218 [hematopoietic stem cell differentiation] GO:2000738 [positive regulation of stem cell differentiation] Show all	413 aa 43.1 kDa	No	0
SP7-005 ENSP00000449355 ENST00000547755	F8VV67 [Direct mapping] Transcription factor Sp7 Show all	Predicted intracellular proteins Show all		269 aa 27 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.