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Gliomas exhibited distinct cytoplasmic immunoreactivity. Colorectal cancers along with several cases of ovarian, endometrial, lung, stomach and pancreatic cancers displayed moderate cytoplasmic and/or membranous positivity. Weak nuclear positivity was observed in testicular cancers. Remaining cancer tissues were in general negative.
GENE INFORMATION
Gene name
DCLK2 (HGNC Symbol)
Synonyms
DCAMKL2, DCDC3, DCDC3B, DCK2, MGC45428
Description
Doublecortin-like kinase 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]
