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Liver cancer and several pancreatic, renal, urothelial, testis, thyroid and breast cancers displayed moderate to strong cytoplasmic and/or luminal membranous immunoreactivity. Remaining cancer tissues were negative or weakly stained.
GENE INFORMATION
Gene name
GPRC5C (HGNC Symbol)
Synonyms
RAIG-3
Description
G protein-coupled receptor, class C, group 5, member C (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Q9NQ84 [Direct mapping] G-protein coupled receptor family C group 5 member C A0A024R8N9 [Target identity:100%; Query identity:100%] G protein-coupled receptor, family C, group 5, member C, isoform CRA_d
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Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
