Tissue expression of ADORA2B - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ADORA2B
Gene description	Adenosine A2b receptor
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	ADORA2B
Synonyms
Description	Adenosine A2b receptor (HGNC Symbol)
Entrez gene summary	This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p12
Chromosome location (bp)	15944917 - 15975746
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170425 (version 83.38)
Entrez gene	136
UniProt	P29275 (UniProt - Evidence at transcript level)
neXtProt	NX_P29275
Antibodypedia	ADORA2B antibodies

PROTEIN BROWSER

ADORA2B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADORA2B-001 ENSP00000304501 ENST00000304222	P29275 [Direct mapping] Adenosine receptor A2b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0000187 [activation of MAPK activity] GO:0001609 [G-protein coupled adenosine receptor activity] GO:0001973 [adenosine receptor signaling pathway] GO:0002882 [positive regulation of chronic inflammatory response to non-antigenic stimulus] GO:0004930 [G-protein coupled receptor activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006968 [cellular defense response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007254 [JNK cascade] GO:0007588 [excretion] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0016021 [integral component of membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0030828 [positive regulation of cGMP biosynthetic process] GO:0031284 [positive regulation of guanylate cyclase activity] GO:0031668 [cellular response to extracellular stimulus] GO:0032722 [positive regulation of chemokine production] GO:0032755 [positive regulation of interleukin-6 production] GO:0043306 [positive regulation of mast cell degranulation] GO:0044267 [cellular protein metabolic process] GO:0060087 [relaxation of vascular smooth muscle] Show all	332 aa 36.3 kDa	No	7