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SLC23A1

GENERAL INFORMATION

Gene name

 SLC23A1

Gene description

 Solute carrier family 23 (ascorbic acid transporter), member 1

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (fallopian tube, small intestine, kidney, duodenum)
GTEx:Group enriched (small intestine, liver, kidney)
FANTOM5:Tissue enhanced (small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Luminal positivity in small intestine and kidney. Also expression in ciliated cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA047612
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (fallopian tube, small intestine, kidney, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, liver, kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION

Gene name

 SLC23A1 (HGNC Symbol)

Synonyms

 SLC23A2, SVCT1, YSPL3

Description

 Solute carrier family 23 (ascorbic acid transporter), member 1 (HGNC Symbol)

Entrez gene summary

 The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Chromosome

 5

Cytoband

 q31.2

Chromosome location (bp)

 139367196 - 139384553

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170482 (version 83.38)

Entrez gene

 9963

UniProt

 Q9UHI7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHI7

Antibodypedia

 SLC23A1 antibodies

PROTEIN BROWSER
SLC23A1-001
SLC23A1-002
SLC23A1-005
SLC23A1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC23A1-001
ENSP00000302701
ENST00000348729
Q9UHI7 [Direct mapping]
Solute carrier family 23 member 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006810 [transport]
GO:0006814 [sodium ion transport]
GO:0007420 [brain development]
GO:0008520 [L-ascorbate:sodium symporter activity]
GO:0009636 [response to toxic substance]
GO:0015081 [sodium ion transmembrane transporter activity]
GO:0015205 [nucleobase transmembrane transporter activity]
GO:0015229 [L-ascorbic acid transporter activity]
GO:0015851 [nucleobase transport]
GO:0015882 [L-ascorbic acid transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019852 [L-ascorbic acid metabolic process]
GO:0033300 [dehydroascorbic acid transporter activity]
GO:0035461 [vitamin transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0043229 [intracellular organelle]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070837 [dehydroascorbic acid transport]
GO:0070890 [sodium-dependent L-ascorbate transmembrane transporter activity]
GO:0070904 [transepithelial L-ascorbic acid transport]
Show all
 598 aa
64.8 kDa 		No >9
SLC23A1-002
ENSP00000302851
ENST00000353963
Q9UHI7 [Direct mapping]
Solute carrier family 23 member 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006810 [transport]
GO:0006814 [sodium ion transport]
GO:0007420 [brain development]
GO:0008520 [L-ascorbate:sodium symporter activity]
GO:0009636 [response to toxic substance]
GO:0009925 [basal plasma membrane]
GO:0015081 [sodium ion transmembrane transporter activity]
GO:0015205 [nucleobase transmembrane transporter activity]
GO:0015229 [L-ascorbic acid transporter activity]
GO:0015851 [nucleobase transport]
GO:0015882 [L-ascorbic acid transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019852 [L-ascorbic acid metabolic process]
GO:0030324 [lung development]
GO:0033300 [dehydroascorbic acid transporter activity]
GO:0035461 [vitamin transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0043229 [intracellular organelle]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070837 [dehydroascorbic acid transport]
GO:0070890 [sodium-dependent L-ascorbate transmembrane transporter activity]
GO:0070904 [transepithelial L-ascorbic acid transport]
Show all
 602 aa
65.2 kDa 		No >9
SLC23A1-005
ENSP00000427271
ENST00000508270
H0YAJ1 [Direct mapping]
Solute carrier family 23 member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0015882 [L-ascorbic acid transport]
GO:0016020 [membrane]
GO:0035461 [vitamin transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070890 [sodium-dependent L-ascorbate transmembrane transporter activity]
Show all
 169 aa
18.9 kDa 		No 1
SLC23A1-009
ENSP00000422688
ENST00000504513
H0Y902 [Direct mapping]
Solute carrier family 23 member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0015882 [L-ascorbic acid transport]
GO:0016020 [membrane]
GO:0035461 [vitamin transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070890 [sodium-dependent L-ascorbate transmembrane transporter activity]
Show all
 136 aa
14 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.