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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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KRT72
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

KRT72

Gene description

Keratin 72, type II

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Group enriched (testis, skin)
FANTOM5:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression

Highly expressed in the hair follicle cuticle layer.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with external characterization data and GTEx RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA065523
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Hair
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Hair

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

KRT72 (HGNC Symbol)

Synonyms

K6irs, K6IRS2, KRT6, KRT6IRS2

Description

Keratin 72, type II (HGNC Symbol)

Entrez gene summary

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. The type II keratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This gene encodes a type II keratin that is specifically expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q12-q13. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2009]

Chromosome

12

Cytoband

q13.13

Chromosome location (bp)

52585589 - 52601538

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170486 (version 83.38)

Entrez gene

140807

UniProt

Q14CN4 (UniProt - Evidence at protein level)

neXtProt

NX_Q14CN4

Antibodypedia

KRT72 antibodies

PROTEIN BROWSER

KRT72-001
KRT72-002
KRT72-004
KRT72-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KRT72-001
ENSP00000441160
ENST00000537672
Q14CN4 [Direct mapping]
Keratin, type II cytoskeletal 72
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005882 [intermediate filament]
GO:0008150 [biological_process]
GO:0045095 [keratin filament]
GO:0070062 [extracellular exosome]
Show all
511 aa
55.9 kDa
No 0
KRT72-002
ENSP00000346269
ENST00000354310
Q14CN4 [Direct mapping]
Keratin, type II cytoskeletal 72
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005882 [intermediate filament]
GO:0008150 [biological_process]
GO:0045095 [keratin filament]
GO:0070062 [extracellular exosome]
Show all
469 aa
51.1 kDa
No 0
KRT72-004
ENSP00000449324
ENST00000549979
H0YIG3 [Direct mapping]
Keratin, type II cytoskeletal 72
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
192 aa
21.7 kDa
No 0
KRT72-201
ENSP00000293745
ENST00000293745
Q14CN4 [Direct mapping]
Keratin, type II cytoskeletal 72
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005882 [intermediate filament]
GO:0008150 [biological_process]
GO:0045095 [keratin filament]
GO:0070062 [extracellular exosome]
Show all
511 aa
55.9 kDa
No 0

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