Cell atlas - IRX1 - The Human Protein Atlas

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IRX1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleoplasm

Human cell
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IRX1
Gene description	Iroquois homeobox 1
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the nucleoplasm.
RNA cell category	Group enriched (REH, U-251 MG, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)
Additional location	In addition localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA043160
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (REH, U-251 MG, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the nucleoplasm.

Main location

Golgi apparatus (supported)

Additional location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043160	A-431	Nucleoplasm
	HPA043160	A-431	Golgi apparatus
	HPA043160	U-2 OS	Nucleoplasm
			Golgi apparatus
			Vesicles
	HPA043160	U-251 MG	Nucleoplasm
	HPA043160	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	IRX1 (HGNC Symbol)
Synonyms	IRX-5
Description	Iroquois homeobox 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	3596054 - 3601403
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170549 (version 83.38)
Entrez gene	79192
UniProt	P78414 (UniProt - Evidence at transcript level)
neXtProt	NX_P78414
Antibodypedia	IRX1 antibodies

PROTEIN BROWSER

IRX1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IRX1-001 ENSP00000305244 ENST00000302006	P78414 [Direct mapping] Iroquois-class homeodomain protein IRX-1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0001656 [metanephros development] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0072086 [specification of loop of Henle identity] GO:0072272 [proximal/distal pattern formation involved in metanephric nephron development] Show all	480 aa 49.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.